Results 41 to 50 of about 199,953 (233)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
On the asymptotic magnitude of subsets of Euclidean space
, 2012 Magnitude is a canonical invariant of finite metric spaces which has its origins in category theory; it is analogous to cardinality of finite sets. Here, by approximating certain compact subsets of Euclidean space with finite subsets, the magnitudes of ...
A. Solow +10 more
core +1 more source
Journal of Mathematical Analysis and Applications, 2012 The authors discuss the boundedness of Calderón-Zygmund operators on non-homogeneous metric measure spaces. They prove that the boundedness of Calderón-Zygmund operators on \(L^2\) is equivalent to either the boundedness of \(T\) from the atomic Hardy space \(H^1\) to \(L^{1,\infty}\) or from \(H^1\) to \(L^1\) on the measure space \((X,d,\mu)\) in the
Liu, Suile, Yang, Dachun, Yang, Dongyong
openaire +2 more sources
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Electronic Journal of Differential Equations, 2007 The paper studies energy functionals on quasimetric spaces, defined by quadratic measure-valued Lagrangeans. This general model of medium, known as metric fractals, includes nested fractals and sub-Riemannian manifolds.
Kyril Tintarev
doaj
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
, 2015 In this work we study the Poisson Boolean model of percolation in locally compact Polish metric spaces and we prove the invariance of subcritical and supercritical phases under mm-quasi-isometries.
Coletti, Cristian F. +2 more
core +1 more source
Boundedness for iterated commutators of multilinear singular integrals of Dini's type on non-homogeneous metric measure spaces [PDF]
SCIENTIA SINICA Mathematica, 2017 Assume that $(\mathcal X, d, \mu)$ is a geometrically doubling metric space and the measure $\mu$ is an upper doubling measure. This paper focuses on studying the boundedness of iterated commutators, which is generated by multilinear singular integral operators with the function $\bm{b}$ in $\mathrm{RBMO}(\mu)$.
TAO XiangXing, ZHENG TaoTao
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