Results 1 to 10 of about 120,353 (299)
Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs
Neurobiology of Disease, 2023 Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disease caused by a CAG repeat expansion in exon1 of the huntingtin gene (HTT).
Huichun Tong +12 more
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Frontiers in Cell and Developmental Biology, 2023 Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the research on the cardiovascular, skin barrier, gastrointestinal, and central nervous systems as ...
Yingqi Lin +16 more
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Signal Transduction and Targeted Therapy, 2023 Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles.
Xiao Zheng +17 more
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Dynamic Regulation of DNA Methylation and Brain Functions
Biology, 2023 DNA cytosine methylation is a principal epigenetic mechanism underlying transcription during development and aging. Growing evidence suggests that DNA methylation plays a critical role in brain function, including neurogenesis, neuronal differentiation ...
Jiaxiang Xie +4 more
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Insights into White Matter Defect in Huntington’s Disease
Cells, 2022 Huntington’s disease (HD) is an autosomal-dominant inherited progressive neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene that is translated to an expanded polyglutamine (PolyQ) repeat in huntingtin protein. HD is
Yize Sun +5 more
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Microbiome Studies in Non-human Primates [PDF]
Current HIV/AIDS Reports, 2021 Observations of differing bacterial, intestinal microbiomes in people living with HIV have propelled interest in contributions of the microbiome to HIV disease. Non-human primate (NHP) models of HIV infection provide a controlled setting for assessing contributions of the microbiome by standardizing environmental confounders.
Brenchley, Jason M., Ortiz, Alexandra M.
openaire +2 more sources
A new non-human primate model of desiccating stress-induced dry eye disease
Scientific Reports, 2022 Dry eye disease (DED), a multifactorial ocular surface disease, is estimated to affect up to 34% of individuals over 50 years old. Although numerous animal models, including rodents and rabbits, have been developed to mimic the pathophysiologic ...
Li Gong +9 more
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Genetically modified large animal models for investigating neurodegenerative diseases
Cell & Bioscience, 2021 Neurodegenerative diseases represent a large group of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease.
Weili Yang +3 more
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Molecular Therapy: Methods & Clinical Development, 2023 The brain is often described as an “immune-privileged” organ due to the presence of the blood-brain-barrier (BBB), which limits the entry of immune cells.
Yaowei Guo +10 more
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A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin
Advanced Science, 2023 Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li +16 more
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