Results 1 to 10 of about 1,031,153 (395)

An Open Resource for Non-human Primate Imaging [PDF]

Neuron, 2018
Non-human primate neuroimaging is a rapidly growing area of research that promises to transform and scale translational and cross-species comparative neuroscience.
Milham, Michael P., Tsao, Doris Y.
core   +23 more sources

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

Nature, 2014
Pluripotent stem cells provide a potential solution to current epidemic rates of heart failure by providing human cardiomyocytes to support heart regeneration.
James J H Chong, Creighton Don, Ping-yen Liu   +2 more
exaly   +2 more sources

Non-human primate pluripotent stem cells for the preclinical testing of regenerative therapies

Neural Regeneration Research, 2022
Non-human primates play a key role in the preclinical validation of pluripotent stem cell-based cell replacement therapies. Pluripotent stem cells used as advanced therapy medical products boost the possibility to regenerate tissues and organs affected ...
Ignacio Rodriguez-Polo, Rüdiger Behr
doaj   +2 more sources

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes [PDF]

Xenotransplantation, 2015
Background Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens.
Adams, A.B., Butler, J.R., Estrada, J., Ford, M.L., Li, P., Martens, G., Newell, K.A., Sidner, R.A., Tector, A.J., Tector, M.   +9 more
core   +2 more sources

Variable responses of human and non-human primate gut microbiomes to a Western diet [PDF]

Microbiome, 2015
BACKGROUND: The human gut microbiota interacts closely with human diet and physiology. To better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models ...
Amato, Katherine R., Cerda, Gabriela, Cramer, Jennifer Danzy, Gomez, Andres, Knight, Rob, Leigh, Steven R., Miller, Margret E. Berg, Nelson, Karen E., Schmitt, Christopher A., Stumpf, Rebecca M., Turner, Trudy R., White, Bryan A., Wilson, Brenda A., Yeoman, Carl J.   +13 more
core   +6 more sources

Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

Nature Nanotechnology, 2023
Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the bloodstream to the brain.
Miguel R. Chuapoco, Nicholas C. Flytzanis, N. Goeden, J. C. Octeau, K. Roxas, Ken Y. Chan, Jon Scherrer, J. Winchester, Roy J. Blackburn, Lillian J. Campos, Kwun Nok, Mimi Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Pal Singh, Cynthia M. Arokiaraj, Timothy F. Shay, Julia Vendemiatti, Min J. Jang, John K. Mich, Yemeserach Bishaw, Bryan B. Gore, Victoria Omstead, Naz Taskin, Natalie Weed, Boaz P. Levi, J. Ting, Cory T. Miller, Benjamin E. Deverman, J. Pickel, L. Tian, A. Fox, V. Gradinaru   +33 more
semanticscholar   +1 more source

Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Frontiers in Cell and Developmental Biology, 2023
Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the research on the cardiovascular, skin barrier, gastrointestinal, and central nervous systems as ...
Yingqi Lin, Caijuan Li, Wei Wang, Jiawei Li, Chunhui Huang, Xiao Zheng, Zhaoming Liu, Xichen Song, Yizhi Chen, Jiale Gao, Jianhao Wu, Jiaxi Wu, Zhuchi Tu, Liangxue Lai, Xiao-Jiang Li, Shihua Li, Sen Yan   +16 more
doaj   +1 more source

Revisiting Darwin's comparisons between human and non-human primate facial signals

Evolutionary Human Sciences, 2022
Abstract Darwin and other pioneering scholars made comparisons between human facial signals and those of non-human primates, suggesting that they share evolutionary history.
Eithne Kavanagh, Clare M Kimock, J. Whitehouse, J. Micheletta, B. Waller   +4 more
semanticscholar   +1 more source

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

Signal Transduction and Targeted Therapy, 2023
Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles.
Xiao Zheng, Chunhui Huang, Yingqi Lin, Bofeng Han, Yizhi Chen, Caijuan Li, Jiawei Li, Yongyan Ding, Xichen Song, Wei Wang, Weien Liang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Chengxi Wei, Xudong Zhang, Zhuchi Tu, Sen Yan   +17 more
doaj   +1 more source

Dynamic Regulation of DNA Methylation and Brain Functions

Biology, 2023
DNA cytosine methylation is a principal epigenetic mechanism underlying transcription during development and aging. Growing evidence suggests that DNA methylation plays a critical role in brain function, including neurogenesis, neuronal differentiation ...
Jiaxiang Xie, Leijie Xie, Huixian Wei, Xiao-Jiang Li, Li Lin   +4 more
doaj   +1 more source