Results 11 to 20 of about 120,353 (299)
Translational Neurodegeneration, 2023 In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and progressive neurodegenerative disease with heterogeneous clinical presentations, researchers have generated numerous animal models to mimic the genetic defects ...
Longhong Zhu +3 more
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Animals, 2022 The Chinese tree shrew (Tupaia belangeri chinensis) has the potential to replace the use of non-human primates in biomedical research. To increase the availability of this species, we have undertaken the ambitious task of establishing inbred lines of the
Jia-Qi Chen +7 more
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Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Signal Transduction and Targeted Therapy, 2023 Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu +13 more
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Comparing HD knockin pigs and mice reveals the pathological role of IL-17
Cell Reports, 2023 Summary: Our previous work has established a knockin (KI) pig model of Huntington’s disease (HD) that can replicate the typical pathological features of HD, including selective striatal neuronal loss, reactive gliosis, and axonal degeneration.
Qingqing Jia +13 more
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Zhongliu Fangzhi Yanjiu, 2023 Objective To investigate the functions of the KIFC1 gene in tumor cells and its effect on the proliferation of cervical cancer cells. Methods We designed sgRNAs targeting the KIFC1 gene and constructed a recombinant plasmid based on the pSpCas9 (BB)-2A ...
FAN Xiaojing +4 more
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Myeloablative irradiation in non‐human primates [PDF]
Journal of Medical Primatology, 2009 AbstractPurpose We used total body irradiation (TBI) as conditioning for cord blood transplantation studies in pigtailed macaques. In these studies, different doses of TBI were explored to obtain optimal myelosuppression with acceptable radiation‐related side effects.Methods Four macaques received TBI ranging from 800 to 1320 cGy, followed by ...
K L, Watts +3 more
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Neuroimaging of Non-Human Primates [PDF]
The Open Neuroimaging Journal, 2011 Welcome to this special issue of the Open Neuroimaging Journal which focuses on neuroimaging studies of non-human primates (NHPs) as presented by leaders in the field. NHPs are important animal models because of their genetic, ontogenic, and physiological similarities to humans.
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Ecotourism disturbances to non-human primates [PDF]
Zoological Research, 2013 In tandem with economic growth and rising living conditions, ecotourism has increasingly gained popularity among the Chinese public. Non-human primates, as charismatic animals and the closest relatives of human beings, have shown a strong affinity in attracting the general public and raising money, and for that reason a variety of monkey parks, valleys,
FAN, Peng-Lai, XIANG, Zuo-Fu
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Cryobiology of non-human primate oocytes [PDF]
Human Reproduction, 1996 The responses to various stresses involved with cryopreservation protocols were investigated using non-human primate oocytes. Fluorescence microscopy was used to assess the status of the F-actin microfilament system of rhesus monkey oocytes after exposure to different concentrations of glycerol.
A I, Younis +3 more
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Bioactive Peptides and Proteins from Centipede Venoms
Molecules, 2022 Venoms are a complex cocktail of biologically active molecules, including peptides, proteins, polyamide, and enzymes widely produced by venomous organisms.
Yalan Han +3 more
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