Results 11 to 20 of about 1,031,153 (395)
An Open Resource for Non-human Primate Optogenetics
Neuron, 2020 Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and ...
S. Tremblay +97 more
semanticscholar +8 more sources
Microbiome Studies in Non-human Primates [PDF]
Current HIV/AIDS Reports, 2021 Observations of differing bacterial, intestinal microbiomes in people living with HIV have propelled interest in contributions of the microbiome to HIV disease. Non-human primate (NHP) models of HIV infection provide a controlled setting for assessing contributions of the microbiome by standardizing environmental confounders.
Jason M. Brenchley, Alexandra M. Ortiz
openaire +3 more sources
Insights into White Matter Defect in Huntington’s Disease
Cells, 2022 Huntington’s disease (HD) is an autosomal-dominant inherited progressive neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene that is translated to an expanded polyglutamine (PolyQ) repeat in huntingtin protein. HD is
Yize Sun +5 more
doaj +1 more source
A new non-human primate model of desiccating stress-induced dry eye disease
Scientific Reports, 2022 Dry eye disease (DED), a multifactorial ocular surface disease, is estimated to affect up to 34% of individuals over 50 years old. Although numerous animal models, including rodents and rabbits, have been developed to mimic the pathophysiologic ...
Li Gong +9 more
doaj +1 more source
Genetically modified large animal models for investigating neurodegenerative diseases
Cell & Bioscience, 2021 Neurodegenerative diseases represent a large group of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease.
Weili Yang +3 more
doaj +1 more source
Nature Communications, 2021 Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and gene expression changes. Early intervention during childhood is thought to benefit prognosis.
Satoshi Watanabe +15 more
semanticscholar +1 more source
Gorillas’ (Gorilla g. gorilla) knowledge of conspecifics’ affordances: intraspecific social tool use for food acquisition [PDF]
, 2020 The use of tools, long thought to be uniquely human, has now been observed in other animal taxa including several species of birds, non-primate mammals as well as some non-human primate species.
Pika, Simone, Prieur, Jacques
core +1 more source
Non-Human Primate Models of Tuberculosis
Microbiology Spectrum, 2016 ABSTRACT Among the animal models of tuberculosis (TB), the non-human primates, particularly rhesus macaques ( Macaca fascicularis ) and cynomolgus macaques ( Macaca mulatta ), share the greatest anatomical and physiological similarities with humans.
J. C. Peña, W. Ho
semanticscholar +3 more sources
The non‐human primate model of tuberculosis [PDF]
Journal of Medical Primatology, 2012 AbstractNon‐human primates (NHPs) are used to model human disease owing to their remarkably similar genomes, physiology, and immune systems. Recently, there has been an increased interest in modeling tuberculosis (TB) in NHPs. Macaques are susceptible to infection with different strains of Mycobacterium tuberculosis (Mtb), producing the full spectrum ...
Peter J. Didier +3 more
openaire +3 more sources