Results 231 to 240 of about 120,353 (299)

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Transcriptional changes in non-human primate tissues after intrathecal delivery of serotype 9 adeno-associated viral vector: Insights into organ toxicities. [PDF]

Mol Ther Methods Clin Dev
Aihara F, Mardo M, Ruda V, Rio TD, Bigot K, Singer J, Onishi-Seebacher M, Couttet P, Mansfield K, Hudry E.   +9 more
europepmc   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

A spinal origin for the obligate flexor synergy in the non-human primate: Implications for control of reaching

Glover IS, Baker AM, Krakauer JW, Baker SN.   +3 more
europepmc   +1 more source

Neuropathogenesis of Encephalitic Alphaviruses in Non-Human Primate and Mouse Models of Infection. [PDF]

Pathogens
Woodson CM, Carney SK, Kehn-Hall K.
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Toward human uterus tissue engineering: Uterine decellularization in a non-human primate species. [PDF]

Acta Obstet Gynecol Scand
De Miguel-Gómez L, Sehic E, Thorén E, Ahlström J, Rabe H, Oltean M, Brännström M, Hellström M.   +7 more
europepmc   +1 more source

Vicarious Touch: A Potential Substitute for Social Touch During Touch Deprivation

European Journal of Social Psychology, EarlyView.
ABSTRACT Restricted interpersonal touch experiences, for instance due to COVID‐19 social distancing measures, result in detrimental effects on anxiety, loneliness and psychological well‐being. Yet, interventions capable of mitigating the impact of social touch deprivation, as experienced during the COVID‐19 pandemic, remain insufficient. In this study,
Louise P. Kirsch, Mariana von Mohr, Athanasios Koukoutsakis, Aikaterini Fotopoulou   +3 more
wiley   +1 more source

Arousal effects on oscillatory dynamics in the non-human primate brain. [PDF]

Cereb Cortex
Anand SA, Sogukpinar F, Monosov IE.
europepmc   +1 more source

One‐Stone‐Two‐Birds Carrier‐Free Nano‐Cocktail Enables Synergistic Eradication of Cancer Cells/Stem Cells in Breast Cancer Treatment

Exploration, EarlyView.
ABSTRACT Cancer stem cells (CSCs) are widely recognized as the culprits of chemoresistance, tumor metastasis, and relapse. Moreover, most chemotherapeutic drugs not only fail to eliminate CSCs effectively, but also induce the acquisition of stemness characteristics in non‐stem cancer cells. Herein, we propose a cancer cells/CSCs double‐killing modality
Tongyao Zhao, Yao Chen, Haimeng Yuan, Shuqian Yang, Hongyuan Zhang, Yuequan Wang, Shenwu Zhang, Qin Chen, Jin Sun, Zhonggui He, Cong Luo   +10 more
wiley   +1 more source