Results 221 to 230 of about 17,406,766 (301)

Short-Term Alcohol Consumption Is Sufficient to Disrupt Microbial Communities and the Intestinal and Circulating Metabolites in a Non-Human Primate Model. [PDF]

FASEB J
Blanton MB, Napier EG, Keen KE, Stuart EV, Cinco IR, Hemati H, Bruntz RC, Khadka R, Grant KA, Messaoudi I.   +9 more
europepmc   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Targeting of specific neuronal types in the non-human primate brain by using a murine CD25-specific recombinant immunotoxin. [PDF]

Sci Rep
Kobayashi T, Kato S, Kimura S, Sugawara M, Ihara K, Ozawa T, Inoue KI, Takada M, Onda M, Kobayashi K.   +9 more
europepmc   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

Metadata assessment of non-human primate studies of AAV9 uncovers potential tissue specific variation in expression efficiency. [PDF]

Gene Ther
Shahrukh M, Sweeney JR, Del Rio T, Ozsolak F.   +3 more
europepmc   +1 more source

Longitudinal investigation of structural and resting-state effective connectivity alterations in a non-human primate model of Huntington's disease. [PDF]

Neurobiol Dis
Petraitytė G, van Rijswijk J, Liguore WA, McBride JL, Verhoye M, Bertoglio D, Weiss AR, Adhikari MH.   +7 more
europepmc   +1 more source

Must Longtermists Wish Us All Dead? A Quadrilemma

Journal of Applied Philosophy, EarlyView.
ABSTRACT Longtermists assign great moral importance to making the long‐term future as good as possible, especially by ensuring the survival of humanity. We argue, to the contrary, that on assumptions that are plausible, conservative, or shared by leading longtermists, human extinction will likely augment total utility among human and non‐human animals ...
Nir Eyal, Bastian Steuwer, Shai Meiri
wiley   +1 more source

Effect of morphology on the biomechanics of contusion models of non-human primate spinal cord injury: a finite element study in a digital population. [PDF]

PLoS One
Obaid N, Zamora DL, Jimenez-Gonzalez C, Sparrey CJ.   +3 more
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Sexually dimorphic responses in androgen metabolism and signalling in the non-human primate placenta to moderate maternal undernutrition. [PDF]

Biol Sex Differ
Meakin AS, Nathanielsz PW, Li C, Clifton VL, Huber HF, Wiese MD, Morrison JL.   +6 more
europepmc   +1 more source