Results 211 to 220 of about 17,406,766 (301)

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

The basal ganglia and the epilepsies

Epilepsia Open, EarlyView.
Abstract The basal ganglia are an evolutionarily conserved neural circuit best known for the selection and sequencing of voluntary movement. Increasing evidence, however, indicates that these structures also play an important role in regulating pathological brain states, including seizures.
Willian Lazarini‐Lopes, Logan Perry, Patrick A. Forcelli   +2 more
wiley   +1 more source

Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate. [PDF]

Sci Rep
Hosoya M, Suda S, Ueno M, Shimanuki MN, Nishiyama T, Oishi N, Ozawa H.   +6 more
europepmc   +1 more source

The translational asymmetry of corpus callosotomy: Two literatures that answered different questions

Epilepsia Open, EarlyView.
Abstract Corpus callosotomy is an established palliative operation for drug‐resistant epilepsy dominated by drop attacks, and it is performed in three extents: anterior, usually of the anterior two‐thirds; total, in one or two stages; and selective posterior, which preserves the genu and rostral body.
Vitória Bernal Cavalcanti, Paulo Henrique Pires de Aguiar   +1 more
wiley   +1 more source

Applied anatomy and morphology of Meibomian glands in the non-human primate. [PDF]

Sci Rep
Moreno IY, Cilli EL, Coulson-Thomas VJ.
europepmc   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Immunization with the pan-fungal vaccine, NXT-2a, reduces fungal burden following serial intravaginal challenges with C. albicans in a non-human primate model of experimental vulvovaginal candidiasis. [PDF]

PLoS One
Wychrij DA, Rabacal W, Chapman TI, Willems HME, Pac CE, Oworae KO, Norris KA.   +6 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

F/HN-pseudotyped lentiviral vector efficiently transduces non-human primate airways with no evidence of relevant toxicity. [PDF]

Mol Ther Adv
Griesenbach U, McLachlan G, Sinadinos A, Cheminay C, Ashour J, Cox J, Schwotzer D, Vyhnal K, Gupta A, Chan M, Meng C, Pineault K, Castells E, Dean RJ, Viegas MA, Boyd AC, Davies JC, Gill DR, Hyde SC, Blanset D, Alton EW.   +20 more
europepmc   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source