Results 51 to 60 of about 1,031,153 (395)

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]

, 2018
Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor, Chen, Haodong, Chour, Tony, Holmström, Alexandra, Itzhaki, Ilanit, Jain, Mohit, Kim, Youngkyun, Lehmann, Kim, Ndoye, Babacar C, Neofytou, Evgenios, Qin, Xulei, Shukla, Praveen, Wu, Joseph C, Xiao, Dan, Yang, Huaxiao, Zhang, Joe Z, Zhao, Mingtao, Zhao, Xin, Zhuge, Yan, Zimmermann, Wolfram-Hubertus   +19 more
core   +3 more sources

High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain

Molecular Therapy: Methods & Clinical Development, 2023
The brain is often described as an “immune-privileged” organ due to the presence of the blood-brain-barrier (BBB), which limits the entry of immune cells.
Yaowei Guo, Junliang Chen, Wenyu Ji, Liang Xu, Yu Xie, Shu He, Chuying Lai, Kaiyu Hou, Zeru Li, Gong Chen, Zheng Wu   +10 more
doaj  

Phytotherapy in zoo animals [PDF]

, 2015
Phytotherapy is one of the oldest medical disciplines and was traditionally based on empiricism (Reichling et al., 2008). Nowadays, its use as an additional integral component of evidence based medicine is well accepted in human medicine (Finkelmann ...
Hoby, S., Walkenhorst, M., Wenker, C.
core   +1 more source

Microbial genomes from non-human primate gut metagenomes expand the primate-associated bacterial tree of life with over 1000 novel species

Genome Biology, 2019
Humans have coevolved with microbial communities to establish a mutually advantageous relationship that is still poorly characterized and can provide a better understanding of the human microbiome.
S. Manara, F. Asnicar, F. Beghini, Davide Bazzani, Fabio Cumbo, Moreno Zolfo, Eleonora Nigro, Nicolai Karcher, P. Manghi, M. I. Metzger, Edoardo Pasolli, N. Segata   +11 more
semanticscholar   +1 more source

Genetic Diagnostic Yield and Novel Causal Genes of Congenital Heart Disease

Frontiers in Genetics, 2022
Congenital heart disease (CHD) is the most common congenital malformation in fetuses and neonates, which also represents a leading cause of mortality.
Meihua Tan, Meihua Tan, Xinrui Wang, Xinrui Wang, Hongjie Liu, Xiaoyan Peng, You Yang, Haifei Yu, Liangpu Xu, Liangpu Xu, Jia Li, Jia Li, Hua Cao, Hua Cao   +13 more
doaj   +1 more source

Cross-species referential signalling events in domestic dogs (Canis familiaris) [PDF]

, 2018
Referential gestures are used by a signaller to draw a recipient’s attention to a specific object, individual or event in the environment. These gestures have received much research attention in relation to human and non-human primates with great apes ...
O'Hara, SJ, Worsley, HK
core   +2 more sources

Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function

Frontiers in Immunology, 2019
The field of HIV research relies heavily on non-human primates, particularly the members of the macaque genus, as models for the evaluation of candidate vaccines and monoclonal antibodies. A growing body of research suggests that successful protection of
A. Crowley, M. Ackerman
semanticscholar   +1 more source

Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection. [PDF]

, 2013
A majority of individuals infected with human immunodeficiency virus (HIV) have inadequate access to antiretroviral therapy and ultimately develop debilitating oral infections that often correlate with disease progression.
A Uehara, Aftab A. Ansari, Angeline T. Dang, AR Thurman, AT Dang, BA Dale, BL Shacklett, BP Gomes, Bruce J. Paster, C Beaurepaire, C Gervasoni, C Heise, Chin-Shang Li, Christina Murphy, D Preza, DA Reznik, DR Dixon, E Elinav, E Zaura, F Meurens, FE Dewhirst, G Diamond, G Diamond, G Xie, H Wang, H Yang, HT Rupniak, I Viard-Leveugle, J Benes, J Mitchell, JA Aas, JA Aas, JC Leao, JE Hull, JE Meyer, JM Garcia-Lechuz, JT Arotiba, L Feller, M Bando, M Bruewer, M Guadalupe, M Mittal, M Raffatellu, MD George, MD George, MD George, MH Shaw, Michael D. George, MP George, MT Pollanen, Niku Borujerdpur, P Regenhard, R Saini, RM Zakir, Ross Tarara, RS Veazey, S Chotai, S Gennaro, S Sugawara, Satya Dandekar, Sumathi Sankaran-Walters, Susan Ocon, T Chen, TG Shrihari, W Hartzell, Z Smit-McBride   +65 more
core   +7 more sources

Ahi1 regulates the nuclear translocation of glucocorticoid receptor to modulate stress response

Translational Psychiatry, 2021
Stress activates the nuclear translocation of glucocorticoid receptors (GR) to trigger gene expression. Abnormal GR levels can alter the stress responses in animals and therapeutic effects of antidepressants.
Bin Wang, Ning Xin, Xuanchen Qian, Lijing Zhai, Zhigang Miao, Yong Yang, Shihua Li, Miao Sun, Xingshun Xu, Xiao-Jiang Li   +9 more
doaj   +1 more source

Topographic organization of the human and non-human primate subthalamic nucleus [PDF]

, 2015
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is used to relieve motor symptoms of Parkinson’s disease. A tripartite system of STN subdivisions serving motoric, associative, and limbic functions was proposed, mainly based on tracing ...
Alfons Schnitzler, Anneke Alkemade, Birte U. Forstmann   +2 more
core   +1 more source