Results 81 to 90 of about 1,031,153 (395)

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Cell Death and Disease
Huntington’s disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein known to interact with many proteins.
Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang   +13 more
doaj   +1 more source

Peptide OPTX-1 From Ornithodoros papillipes Tick Inhibits the pS273R Protease of African Swine Fever Virus

Frontiers in Microbiology, 2021
African swine fever virus (ASFV) is a large double-stranded DNA virus and causes high mortality in swine. ASFV can be transmitted by biological vectors, including soft ticks in genus Ornithodoros but not hard ticks.
Jingjing Wang, Jingjing Wang, Mengyao Ji, Bingqian Yuan, Anna Luo, Zhenyuan Jiang, Zhenyuan Jiang, Tengyu Zhu, Tengyu Zhu, Yang Liu, Yang Liu, Peter Muiruri Kamau, Lin Jin, Lin Jin, Ren Lai, Ren Lai, Ren Lai, Ren Lai   +17 more
doaj   +1 more source

Human and Non-Human Primate Intestinal FcRn Expression and Immunoglobulin G Transcytosis [PDF]

, 2013
PURPOSE: To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal antibodies (mAbs).
Amanda L. Kauffman, Benjamin Harman, Connie Kliwinski, Edwin Ragwan, Gordon D. Powers, Haimanti Dorai, Jill Giles-Komar, John R. Mabus, Pamela J. Hornby, Philip R. Cooper, Susan H. Tam, Suzanne Thompson, Zhengyin Yan   +12 more
core   +1 more source

Meaningful call combinations in a non-human primate [PDF]

Current Biology, 2008
SummaryHuman speech is based on rule-governed assemblage of morphemes into more complex vocal expressions. Free-ranging putty-nosed monkeys (Cercopithecus nictitans) provide an interesting analogy, because males combine two loud alarm calls, ‘hacks’ and ‘pyows’, into different call series depending on external events [1].
Arnold, Kate, Zuberbuhler, Klaus
openaire   +6 more sources

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Revised recommendations for health monitoring of non-human primate colonies (2018): FELASA Working Group Report

Laboratory Animals. Journal of the Laboratory Animal Science Association, 2019
The genetic and biological similarity between non-human primates and humans has ensured the continued use of primates in biomedical research where other species cannot be used.
Ivan Balansard, Lorna Cleverley, K. Cutler, M. Spångberg, K. Thibault-Duprey, J. Langermans   +5 more
semanticscholar   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata

NeuroImage, 2021
Sharing and pooling large amounts of non-human primate neuroimaging data offer new exciting opportunities to understand the primate brain. The potential of big data in non-human primate neuroimaging could however be tremendously enhanced by combining ...
Colline Poirier, Suliann Ben Hamed, Pamela Garcia-Saldivar, Sze Chai Kwok, Adrien Meguerditchian, Hugo Merchant, Jeffrey Rogers, Sara Wells, Andrew S. Fox   +8 more
doaj  

Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future. [PDF]

, 2017
The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages ...
Miller, Lisa, Pinkerton, Kent, Royer, Christopher, Schelegle, Edward   +3 more
core   +1 more source