Results 141 to 150 of about 165,398 (266)

The Primate Welfare INdicators project (PWIN): For an objective and standardised welfare assessment of non-human primates used in research. [PDF]

Anim Welf
Caspar-Cohen J, Demellier J, Pellé S, Valenchon M, Ravel S, Romain A, Petit O.   +6 more
europepmc   +1 more source

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

Animal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong, Ning Liu, Weining Kong, Xiang Gao, Feifei Guan, Shan Gao, Yuanwu Ma   +6 more
wiley   +1 more source

Peptide nanoparticles for systemic mRNA delivery in rodents and non-human primates

Lehto T, Lehto T, Sork H, Lorents A, Rädler J, Bazaz S, Roudi S, Gustafsson O, Boukary O, Talgre I, Hällbrink M, Wiklander O, Saher O, Bost J, Ezzat K, Smith E, Gupta D, Andaloussi SE.   +17 more
europepmc   +2 more sources

Shared signatures of alcohol-associated dysbiosis in humans and non-human primates. [PDF]

Curr Res Microb Sci
Chen T, Huang R, Huang Y, Wang J, Wang Z, Zhang X.   +5 more
europepmc   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

Long-term protective potency of AAV vector-based SARS-CoV-2 prophylaxis in mice and non-human primates. [PDF]

Front Immunol
Ryabova EI, Derkaev AA, Esmagambetov IB, Dovgiy MA, Gordeychuk IV, Shuliakova IV, Hossain RM, Blinov AA, Iliukhina AA, Grousova DM, Zorkov ID, Avdoshina DV, Gulyaev SA, Apolokhov VD, Gulyaeva TV, Favorskaya IA, Shcheblyakov DV, Gintsburg AL, Logunov DY.   +18 more
europepmc   +1 more source

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Transient changes in body weight and behavior during the placentation period in non-human primates and rodents. [PDF]

Sci Rep
Yano-Nashimoto S, Shinozuka K, Kurachi T, Kagawa K, Sakamoto KQ, Shigeno Y, Niimi K, Kuroda KO, Yamaguchi S.   +8 more
europepmc   +1 more source

Prediction of Human Serum Concentration–Time Profiles of Golimumab and Ustekinumab Using Pharmacokinetic Data From Common Marmosets With Assessment of Anti‐Drug Antibodies

Biopharmaceutics &Drug Disposition, EarlyView.
This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri, Shogo Matsumoto, Nanami Furukawa, Kensuke Kagiyama, Hiroshi Ikeda, Kazumasa Fukasawa, Hiroki Takano   +6 more
wiley   +1 more source

Preclinical safety evaluation of the dipeptidyl peptidase 3 inhibiting antibody Procizumab in rodents and non-human primates. [PDF]

MAbs
van Lier D, Genest M, Picod A, Manicone F, Garcia B, Uba TI, Schroeter A, Santos K, Herpain A, Nguyen A, Azibani F, Mebazaa A, Kox M, Pickkers P.   +13 more
europepmc   +1 more source