Results 121 to 130 of about 188,969 (307)

Prevalence of intestinal trichomonads in captive non-human primates in China

Parasite
Trichomonads are protozoan symbionts with the capacity to infect vertebrates including humans and non-human primates (NHPs), sometimes with pathogenic effects. However, their diversity and prevalence in NHPs in China are poorly understood. A total of 533
Ma Ping-Ping, Zou Yang, Mu Wen-Jie, Zhang Yue-Yue, Li Ya-Qi, Liu Zhong-Li, Zhang Long, Chen Li-Xian, Liu Guo-Hua, Wang Shuai   +9 more
doaj   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Gating elements for carvacrol activation of the OTOP1 proton channel

Communications Biology
Otopetrin 1 (OTOP1) is a proton-activated channel crucial for animals’ perception of sour taste. Despite its significance, the gating mechanism of OTOP1 remains poorly understood.
Jingmei Hu, Yalan Han, Anna Luo, Hao Zhang, Lifeng Tian, Huajun Cai, Beiru Xue, Ren Lai, Lei Luo   +8 more
doaj   +1 more source

Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses.: Favipiravir pharmacokinetics in non-human primates

, 2016
International audienceFavipiravir is a RNA polymerase inhibitor that showed a strong antiviral efficacy in vitro and in small animal models of several viruses responsible for hemorrhagic fever (HF) including Ebola virus.
Yamada, Koichi, Raoul, Hervé, Nguyen, Thi Huyen Tram, Jacquot, Frédéric, Guedj, Jérémie, Mentré, France, Oestereich, Lisa, Taburet, Anne-Marie, Kadota, Takumi, de Lamballerie, Xavier, Madelain, Vincent   +10 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Neuroimmunology research in non-human primates

, 2013
Multiple sclerosis (MS) is one of the most intensively studied immune-based inflammatory diseases (IMID) of the human central nervous system. Experimental autoimmune encephalomyelitis (EAE) is the elected animal model of MS in which immunopathogenic ...
Amor, Sandra, Hart, Bert A T, Jagessar, Anwar, Kap, Yolanda S., Brok, Herbert P M   +4 more
core   +1 more source

Extensive diversity of intestinal trichomonads of non-human primates

, 2011
SUMMARYDespite the fact that the non-human primates are our closest relatives and represent a species-rich mammalian group, little is known about their intestinal protistan parasites/commensals.
KLÁRA J. PETRŽELKOVÁ, PAVLA SMEJKALOVÁ, IVAN ČEPIČKA, KATEŘINA POMAJBÍKOVÁ, DAVID MODRÝ   +4 more
core   +1 more source

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

Intuitive statistics in non-human primates

, 2012
Background / Purpose: This study investigates intuitive statistics in non-human primates (chimpanzees, bonobos, gorillas and orangutans) and is based on previous work on intuitive statistics in human infants (1).
Clüver, Annette, Saucke, Liane, Migura, Judith, Call, Josep, Gräbener, Alice, Stoffregen, Nicole, Rakoczy, Hannes   +6 more
core   +1 more source