Results 101 to 110 of about 16,594,316 (254)

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Depletion of giant ANK2 in monkeys causes drastic brain volume loss

Cell Discovery, 2021
Dong-Dong Qin, Jian-Kui Zhou, Xie-Chao He, Xiang-Yu Shen, Cong Li, Huan-Zhi Chen, Lan-Zhen Yan, Zheng-Fei Hu, Xiang Li, Long-Bao Lv, Yong-Gang Yao, Zheng Wang, Xing-Xu Huang, Xin-Tian Hu, Ping Zheng   +14 more
doaj   +1 more source

Reemergence of yellow fever in the state of São Paulo: the structuring role of surveillance of epizootics in non-human primates in a one health approach [PDF]

Revista Brasileira de Epidemiologia
Objective: to present a comprehensive analysis of YF occurrence of in the state of São Paulo since its reemergence, and the ongoing process of structuring the surveillance of epizootics in non-human primates in a one health approach.
Leila del Castillo Saad, Francisco Chiaravalloti-Neto   +1 more
doaj   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy

Cell Discovery, 2022
Guanqin Ma, Deng-Feng Zhang, Qing-Cui Zou, Xiaochun Xie, Ling Xu, Xiao-Li Feng, Xiaohong Li, Jian-Bao Han, Dandan Yu, Zhong-Hua Deng, Wang Qu, Junyi Long, Ming-Hua Li, Yong-Gang Yao, Jianxiong Zeng   +14 more
doaj   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Non-human primates: The appropriate subjects of biomedical research? [PDF]

, 2007
Following the publication of the Weatherall report on the use of non-human primates in research, this paper reflects on how to provide appropriate and ethical models for research beneficial to humankind.
Quigley, Muireann, Quigley, Muireann; id_orcid   +1 more
core   +1 more source

A novel, non-toxic chitosan modified with lysine to enhance buffer capacity for siRNA delivery

Pakistan Journal of Pharmaceutical Sciences
The present study employed lysine as a modifying agent for chitosan (CS) to synthesise a novel CS derivative (LGCS) intended for siRNA delivery. The successful grafting of lysine to CS was characterized using FT-IR and the introduction of the lysine ...
Tianhui Liu, Mei Lin, Chengfei Zhao, Aizhu Lin, Putian, China Fuzhou, China   +6 more
doaj   +1 more source

Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates.

PLoS Neglected Tropical Diseases, 2018
Many human parasites and pathogens have closely related counterparts among non-human primates. For example, non-human primates harbour several species of malaria causing parasites of the genus Plasmodium.
Jyotsana Dixit, Arun Zachariah, Sajesh P K, Bathrachalam Chandramohan, Vinoth Shanmuganatham, K Praveen Karanth   +5 more
doaj   +1 more source