Results 81 to 90 of about 165,398 (266)

Defining a core breath profile for healthy, non-human primates

Scientific Reports
Non-human primates remain the most useful and reliable pre-clinical model for many human diseases. Primate breath profiles have previously distinguished healthy animals from diseased, including non-human primates.
Carly A. Bobak, Keisean A. J. M. Stevenson, Ning Sun, Mohammad S. Khan, Jannatul Azmir, Marco Beccaria, Jaime A. Tomko, Daniel Fillmore, Charles A. Scanga, Philana L. Lin, JoAnne L. Flynn, Jane E. Hill   +11 more
doaj   +1 more source

A novel, non-toxic chitosan modified with lysine to enhance buffer capacity for siRNA delivery

Pakistan Journal of Pharmaceutical Sciences
The present study employed lysine as a modifying agent for chitosan (CS) to synthesise a novel CS derivative (LGCS) intended for siRNA delivery. The successful grafting of lysine to CS was characterized using FT-IR and the introduction of the lysine ...
Tianhui Liu, Mei Lin, Chengfei Zhao, Aizhu Lin, Putian, China Fuzhou, China   +6 more
doaj   +1 more source

Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates.

PLoS Neglected Tropical Diseases, 2018
Many human parasites and pathogens have closely related counterparts among non-human primates. For example, non-human primates harbour several species of malaria causing parasites of the genus Plasmodium.
Jyotsana Dixit, Arun Zachariah, Sajesh P K, Bathrachalam Chandramohan, Vinoth Shanmuganatham, K Praveen Karanth   +5 more
doaj   +1 more source

Non-human primates as a model for aging

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
There has been, and continues to be, a dramatic shift in the human population towards older ages necessitating biomedical research aimed at better understanding the basic biology of aging and age-related diseases and facilitating new and improved therapeutic options.
openaire   +2 more sources

Quantum‐Like Dynamics in Whole‐Brain Models of the Human Connectome

Advanced Science, EarlyView.
Quantum‐like dynamics in the human brain. The level of quantum‐like behavior in a non‐quantum system of coupled oscillators is regulated by the spectral gap of the coupling graph. Whole‐brain modelling using QL fits the empirical data significantly better and has a lower model‐derived energy cost than the non‐QL model.
Gustavo Deco, Yonatan Sanz Perl, Natasha Greenstein, Shamil Chandaria, Gregory Scholes, Morten L. Kringelbach   +5 more
wiley   +1 more source

From Sourcing to End‐of‐Life: Sustainability Challenges and Opportunities in Organic Bioelectronics

Advanced Science, EarlyView.
Organic bioelectronics bridges biology and electronics using organic mixed ionic/electronic conductors. This Perspective addresses sustainability across the full lifecycle of organic bioelectronic materials and devices, offering a framework to guide material sourcing, synthesis, fabrication, application, and end‐of‐life strategies toward bioelectronic ...
Gwennaël Dufil, Marine Batista, Andrea Bionda, Erica Zeglio   +3 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Prevalence of intestinal trichomonads in captive non-human primates in China

Parasite
Trichomonads are protozoan symbionts with the capacity to infect vertebrates including humans and non-human primates (NHPs), sometimes with pathogenic effects. However, their diversity and prevalence in NHPs in China are poorly understood. A total of 533
Ma Ping-Ping, Zou Yang, Mu Wen-Jie, Zhang Yue-Yue, Li Ya-Qi, Liu Zhong-Li, Zhang Long, Chen Li-Xian, Liu Guo-Hua, Wang Shuai   +9 more
doaj   +1 more source