Results 81 to 90 of about 16,594,316 (254)

Transferrin Disassociates TCR from CD3 Signaling Apparatus to Promote Metastasis

Research
Immune recognition and activation by the peptide-laden major histocompatibility complex–T cell receptor (TCR)–CD3 complex is essential for anti-tumor immunity. Tumors may escape immune surveillance by dissembling the complex.
Ruomei Cheng, Xiaopeng Tang, Qiyu Zhao, Yuming Wang, Wenlin Chen, Gan Wang, Chenxi Wang, James Mwangi, Qiumin Lu, Dawit Adisu Tadese, Xudong Zhao, Caiwen Ou, Ren Lai   +12 more
doaj   +1 more source

Evidence of MAYV infection in non-human primates.

, 2021
Evidence of MAYV infection in non-human primates.
Barbara A. Han (11831794), Neida Karen Mita-Mendoza (11831797), Bernard Okech (3172848), Brett M. Forshey (7465544), Assaf Anyamba (186894), Ricardo Khouri (149050), Simon Pollett (846687), James Dunford (2060599), George Rutherford (3660), Elizabet Lilia Estallo (9231032), Isadora Cristina de Siqueira (7392599), Michael Celone (11831791)   +11 more
core   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Application of biochemical and polymerase chain reaction assays for identification of Campylobacter isolates from non-human primates

Memorias do Instituto Oswaldo Cruz, 2006
A multiplex polymerase chain reaction (PCR) assay was performed on 167 thermophilic campylobacters isolated from non-human primates. Samples were first identified by phenotypic methods resulting in 64 Campylobacter jejuni and 103 C. coli strains.
Mônica de Castro Britto Vilardo, Jacqueline Darc da Silva Thomé, Wagner Thadeu Cardoso Esteves, Ana Luzia Lauria Filgueiras, Selma Soares de Oliveira   +4 more
doaj   +1 more source

Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex

Nature Communications, 2020
Non-human primates are useful models for understanding the human brain but application of optogenetics to non-human primates is challenging. The authors used optogenetic intracortical microstimulation in the primary motor cortex of macaques to elicit ...
Hidenori Watanabe, Hiromi Sano, Satomi Chiken, Kenta Kobayashi, Yuko Fukata, Masaki Fukata, Hajime Mushiake, Atsushi Nambu   +7 more
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Animal models of the non-motor features of Parkinson's disease

Neurobiology of Disease, 2012
The non-motor symptoms (NMS) of Parkinson's disease (PD) occur in roughly 90% of patients, have a profound negative impact on their quality of life, and often go undiagnosed.
Kimberly McDowell, Marie-Françoise Chesselet   +1 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Use of adeno-associated virus-mediated delivery of mutant huntingtin to study the spreading capacity of the protein in mice and non-human primates

Neurobiology of Disease, 2020
In order to model various aspects of Huntington's disease (HD) pathology, in particular protein spread, we administered adeno-associated virus (AAV) expressing green fluorescent protein (GFP) or GFP coupled to HTT-Exon1 (19Q or 103Q) to the central ...
Alexander Maxan, Giacomo Sciacca, Melanie Alpaugh, Zhu Tao, Ludivine Breger, Benjamin Dehay, Zhang Ling, Qin Chuan, Giulia Cisbani, Maria Masnata, Shireen Salem, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti   +14 more
doaj   +1 more source

Detection by PCR and isolation assays of the anaerobic intestinal spirochete Brachyspira aalborgi from the feces of captive nonhuman primates [PDF]

, 2003
The purpose of this study was to investigate the presence of the anaerobic intestinal spirochetes Brachyspira aalborgi and Brachyspira pilosicoli in the feces of captive nonhuman primates (n = 35) from 19 species housed at the Zoological Gardens, Perth ...
Taylor, N.M., Munshi, M.A., Hampson, D.J., Mikosza, A.S.J., Spencer, P.B.S.   +4 more
core