Results 11 to 20 of about 156,532 (260)

Construction and investigation of a circRNA-associated ceRNA regulatory network in Tetralogy of Fallot

open access: yesBMC Cardiovascular Disorders, 2021
Background As the most frequent type of cyanotic congenital heart disease (CHD), tetralogy of Fallot (TOF) has a relatively poor prognosis without corrective surgery.
Haifei Yu, Xinrui Wang, Hua Cao
doaj   +1 more source

Comparative metabolomics in primates reveals the effects of diet and gene regulatory variation on metabolic divergence. [PDF]

open access: yes, 2014
Human diets differ from those of non-human primates. Among few obvious differences, humans consume more meat than most non-human primates and regularly cook their food.
Blekhman, Ran   +5 more
core   +2 more sources

Myeloablative irradiation in non‐human primates [PDF]

open access: yesJournal of Medical Primatology, 2009
AbstractPurpose  We used total body irradiation (TBI) as conditioning for cord blood transplantation studies in pigtailed macaques. In these studies, different doses of TBI were explored to obtain optimal myelosuppression with acceptable radiation‐related side effects.Methods  Four macaques received TBI ranging from 800 to 1320 cGy, followed by ...
K L, Watts   +3 more
openaire   +2 more sources

Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis

open access: yesActa Pharmaceutica Sinica B, 2022
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis.
Gan Wang   +21 more
doaj   +1 more source

Variable responses of human and non-human primate gut microbiomes to a Western diet [PDF]

open access: yes, 2015
BACKGROUND: The human gut microbiota interacts closely with human diet and physiology. To better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models ...
Amato, Katherine R.   +13 more
core   +5 more sources

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

open access: yesCell Death and Disease, 2020
COVID-19, caused by SARS-CoV-2, is an acute and rapidly developing pandemic, which leads to a global health crisis. SARS-CoV-2 primarily attacks human alveoli and causes severe lung infection and damage.
Peng Wang   +12 more
doaj   +1 more source

Tool use induces complex and flexible plasticity of human body representations [PDF]

open access: yes, 2012
Plasticity of body representation fundamentally underpins human tool use. Recent studies have demonstrated remarkably complex plasticity of body representation in humans, showing that such plasticity: (1) occurs flexibly across multiple time-scales, and (
Longo, Matthew R., Serino, A.
core   +1 more source

Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Zika virus (ZIKV), which preferentially targets neural stem and progenitor cells (NSCs) especially in developing brain, is causally associated with fetal microcephaly, intrauterine retardation, and other congenital malformations in humans. However, there
Xiaochun Xie   +3 more
doaj   +1 more source

Neuroimaging of Non-Human Primates [PDF]

open access: yesThe Open Neuroimaging Journal, 2011
Welcome to this special issue of the Open Neuroimaging Journal which focuses on neuroimaging studies of non-human primates (NHPs) as presented by leaders in the field. NHPs are important animal models because of their genetic, ontogenic, and physiological similarities to humans.
openaire   +2 more sources

Ecotourism disturbances to non-human primates [PDF]

open access: yesZoological Research, 2013
In tandem with economic growth and rising living conditions, ecotourism has increasingly gained popularity among the Chinese public. Non-human primates, as charismatic animals and the closest relatives of human beings, have shown a strong affinity in attracting the general public and raising money, and for that reason a variety of monkey parks, valleys,
FAN, Peng-Lai, XIANG, Zuo-Fu
openaire   +2 more sources

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