Results 1 to 10 of about 188,969 (307)

Challenges of modeling pristane‐induced lupus in non‐human primates [PDF]

Animal Models and Experimental Medicine
A lupus‐like condition induced by intraperitoneal administration of pristane (2,6,10,14‐tetramethylpentadecane) in mice is widely used as a model of systemic lupus erythematosus (SLE). Due to their phylogenetic distance from humans, murine models are not
Elena Vladimirovna Vinogradova, Maria Alexandrovna Varavko, Yakov Yuryevich Ustyugov, Alexey Alexandrovich Aleksandrov, Dmitry Alexandrovich Khochenkov, Yulia Nikolaevna Linkova   +5 more
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Optimization of Milk Substitutes for the Artificial Rearing of Chinese Tree Shrews (Tupaia belangeri chinensis)

Animals, 2022
The Chinese tree shrew (Tupaia belangeri chinensis) has the potential to replace the use of non-human primates in biomedical research. To increase the availability of this species, we have undertaken the ambitious task of establishing inbred lines of the
Jia-Qi Chen, Qingyu Zhang, Dandan Yu, Rui Bi, Yuhua Ma, Yijiang Li, Long-Bao Lv, Yong-Gang Yao   +7 more
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Antioxidant Activity and Anti-Apoptotic Effect of the Small Molecule Procyanidin B1 in Early Mouse Embryonic Development Produced by Somatic Cell Nuclear Transfer

Molecules, 2021
As an antioxidant, procyanidin B1(PB1) can improve the development of somatic cell nuclear transfer (SCNT) embryos; PB1 reduces the level of oxidative stress (OS) during the in vitro development of SCNT embryos by decreasing the level of reactive oxygen ...
Wei Gao, Tingting Yu, Guomeng Li, Wei Shu, Yongxun Jin, Mingjun Zhang, Xianfeng Yu   +6 more
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Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice

EBioMedicine, 2022
Summary: Background: The Coronavirus Disease 2019 (COVID-19) pandemic has been a great threat to global public health since 2020. Although the advance on vaccine development has been largely achieved, a strategy to alleviate immune overactivation in ...
Jianxiong Zeng, Xiaochun Xie, Xiao-Li Feng, Ling Xu, Jian-Bao Han, Dandan Yu, Qing-Cui Zou, Qianjin Liu, Xiaohong Li, Guanqin Ma, Ming-Hua Li, Yong-Gang Yao   +11 more
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Bioactive Peptides and Proteins from Centipede Venoms

Molecules, 2022
Venoms are a complex cocktail of biologically active molecules, including peptides, proteins, polyamide, and enzymes widely produced by venomous organisms.
Yalan Han, Peter Muiruri Kamau, Ren Lai, Lei Luo   +3 more
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Bioactive Peptides and Proteins from Wasp Venoms

Biomolecules, 2022
Wasps, members of the order Hymenoptera, use their venom for predation and defense. Accordingly, their venoms contain various constituents acting on the circulatory, immune and nervous systems.
Lei Luo, Peter Muiruri Kamau, Ren Lai
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Anticarin β Inhibits Human Glioma Progression by Suppressing Cancer Stemness via STAT3

Frontiers in Oncology, 2021
Glioma is the most common form of malignant brain cancer. It is very difficult to cure malignant glioma because of the presence of glioma stem cells, which are a barrier to cure, have high tumorigenesis, associated with drug resistance, and responsible ...
Min Zhang, Min Zhang, Zhi Dai, Xudong Zhao, Gan Wang, Ren Lai   +5 more
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Construction and investigation of a circRNA-associated ceRNA regulatory network in Tetralogy of Fallot

BMC Cardiovascular Disorders, 2021
Background As the most frequent type of cyanotic congenital heart disease (CHD), tetralogy of Fallot (TOF) has a relatively poor prognosis without corrective surgery.
Haifei Yu, Xinrui Wang, Hua Cao
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A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

Cell Death and Disease, 2020
COVID-19, caused by SARS-CoV-2, is an acute and rapidly developing pandemic, which leads to a global health crisis. SARS-CoV-2 primarily attacks human alveoli and causes severe lung infection and damage.
Peng Wang, Ronghua Luo, Min Zhang, Yaqing Wang, Tianzhang Song, Tingting Tao, Zhongyu Li, Lin Jin, Hongyi Zheng, Wenwen Chen, Mengqian Zhao, Yongtang Zheng, Jianhua Qin   +12 more
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Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis

Acta Pharmaceutica Sinica B, 2022
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis.
Gan Wang, Min Zhang, Ping Meng, Chengbo Long, Xiaodong Luo, Xingwei Yang, Yunfei Wang, Zhiye Zhang, James Mwangi, Peter Muiruri Kamau, Zhi Dai, Zunfu Ke, Yi Zhang, Wenlin Chen, Xudong Zhao, Fei Ge, Qiumin Lv, Mingqiang Rong, Dongsheng Li, Yang Jin, Xia Sheng, Ren Lai   +21 more
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