Results 11 to 20 of about 165,398 (266)

Microbiome Studies in Non-human Primates [PDF]

open access: yesCurrent HIV/AIDS Reports, 2021
Observations of differing bacterial, intestinal microbiomes in people living with HIV have propelled interest in contributions of the microbiome to HIV disease. Non-human primate (NHP) models of HIV infection provide a controlled setting for assessing contributions of the microbiome by standardizing environmental confounders.
Brenchley, Jason M., Ortiz, Alexandra M.
openaire   +2 more sources

Construction and investigation of a circRNA-associated ceRNA regulatory network in Tetralogy of Fallot

open access: yesBMC Cardiovascular Disorders, 2021
Background As the most frequent type of cyanotic congenital heart disease (CHD), tetralogy of Fallot (TOF) has a relatively poor prognosis without corrective surgery.
Haifei Yu, Xinrui Wang, Hua Cao
doaj   +1 more source

Myeloablative irradiation in non‐human primates [PDF]

open access: yesJournal of Medical Primatology, 2009
AbstractPurpose  We used total body irradiation (TBI) as conditioning for cord blood transplantation studies in pigtailed macaques. In these studies, different doses of TBI were explored to obtain optimal myelosuppression with acceptable radiation‐related side effects.Methods  Four macaques received TBI ranging from 800 to 1320 cGy, followed by ...
K L, Watts   +3 more
openaire   +2 more sources

Neuroimaging of Non-Human Primates [PDF]

open access: yesThe Open Neuroimaging Journal, 2011
Welcome to this special issue of the Open Neuroimaging Journal which focuses on neuroimaging studies of non-human primates (NHPs) as presented by leaders in the field. NHPs are important animal models because of their genetic, ontogenic, and physiological similarities to humans.
openaire   +2 more sources

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

open access: yesCell Death and Disease, 2020
COVID-19, caused by SARS-CoV-2, is an acute and rapidly developing pandemic, which leads to a global health crisis. SARS-CoV-2 primarily attacks human alveoli and causes severe lung infection and damage.
Peng Wang   +12 more
doaj   +1 more source

Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis

open access: yesActa Pharmaceutica Sinica B, 2022
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis.
Gan Wang   +21 more
doaj   +1 more source

Neuroimmune Evasion of Zika Virus to Facilitate Viral Pathogenesis

open access: yesFrontiers in Cellular and Infection Microbiology, 2021
Zika virus (ZIKV), which preferentially targets neural stem and progenitor cells (NSCs) especially in developing brain, is causally associated with fetal microcephaly, intrauterine retardation, and other congenital malformations in humans. However, there
Xiaochun Xie   +3 more
doaj   +1 more source

Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2

open access: yesSignal Transduction and Targeted Therapy, 2021
Understanding the pathological features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in an animal model is crucial for the treatment of coronavirus disease 2019 (COVID-19).
Hong-Yi Zheng   +13 more
doaj   +1 more source

Localization of b-defensin genes in non human primates

open access: yesEuropean Journal of Histochemistry, 2009
Defensins are a family of host defence peptides that play an important role in the innate immunity of mammalian and avian species. In humans, four b-defensins have been isolated so far, corresponding to the products of the genes DEFB1 (h-BD1, GenBank ...
M Ventura   +3 more
doaj   +1 more source

Seroprevalence of Hepatitis A virus infection in non-human primates in Assam, India

open access: yesJournal of Threatened Taxa, 2013
The present study investigated 37 serum samples of non-human primates in Assam State Zoo and the Department of Forest and Environment, Govt. of Assam for seroprevalence of hepatitis A virus infection during the period from December, 2007 to November ...
B.G. Nath   +4 more
doaj   +1 more source

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