Results 21 to 30 of about 15,755 (254)

Non-Invasive Prenatal Testing (NIPT): Reliability, Challenges, and Future Directions

Diagnostics, 2023
Non-invasive prenatal testing was first discovered in 1988; it was primarily thought to be able to detect common aneuploidies, such as Patau syndrome (T13), Edward Syndrome (T18), and Down syndrome (T21).
Siva Shantini Jayashankar, Muhammad Luqman Nasaruddin, Muhammad Faiz Hassan, Rima Anggrena Dasrilsyah, Mohamad Nasir Shafiee, Noor Akmal Shareela Ismail, Ekram Alias   +6 more
doaj   +1 more source

Controversies in implementing non‐invasive prenatal testing in a public antenatal care program

Acta Obstetricia et Gynecologica Scandinavica, 2022
Women's autonomy and an inclusive society for all individuals are highly valued in Norway. The Norwegian Biotechnology Act changed in 2020 allowing first‐trimester screening and cell‐free DNA for common trisomies to all pregnant women.
Kjell Åsmund Blix Salvesen, Ragnhild Glad, Vasilis Sitras   +2 more
doaj   +1 more source

Challenges and clinical implications of discordant non-invasive prenatal testing results: insights from two case studies [PDF]

Folia Medica
Non-invasive prenatal testing (NIPT) has transformed prenatal screening, offering high sensitivity and specificity in the detection of common fetal aneuploidies.
Slavyana Galeva, Boris Stoilov, Ekaterina Uchikova   +2 more
doaj   +3 more sources

Genetic Counseling and Management: The First Study to Report NIPT Findings in a Romanian Population

Medicina, 2022
Background and Objectives: Non-invasive prenatal testing (NIPT) has been confirmed as the most accurate screening test for trisomies 21, 18, 13, sex chromosomes aneuploidies and several microdeletions. This study aimed to assess the accuracy of cell free
Cristina Gug, Ioana Mozos, Adrian Ratiu, Anca Tudor, Eusebiu Vlad Gorduza, Lavinia Caba, Miruna Gug, Catalina Cojocariu, Cristian Furau, Gheorghe Furau, Monica Adriana Vaida, Dorina Stoicanescu   +11 more
doaj   +1 more source

Non‐invasive prenatal testing in the management of twin pregnancies [PDF]

Prenatal Diagnosis, 2021
AbstractTwin pregnancies are common and associated with pregnancy complications and adverse outcomes. Prenatal clinical management is intensive and has been hampered by inferior screening and less acceptable invasive testing. For aneuploidy screening, meta‐analyses show that non‐invasive prenatal testing (NIPT) through analysis of cell‐free DNA (cf‐DNA)
Peter Benn, Andrei Rebarber
openaire   +2 more sources

A placental trisomy 2 detected by NIPT evolved in a fetal small Supernumerary Marker Chromosome (sSMC)

Molecular Cytogenetics, 2021
Background Non-invasive prenatal testing (NIPT) is a rapidly developing and widely used method in the prenatal screening. Recently, the widespread use of the NIPT caused a neglecting of the limitations of this technology.
Justyna Domaradzka, Marta Deperas, Ewa Obersztyn, Anna Kucińska-Chahwan, Nathalie Brison, Kris Van Den Bogaert, Tomasz Roszkowski, Marta Kędzior, Magdalena Bartnik-Głaska, Alicja Łuszczek, Krystyna Jakubów-Durska, Joris Robert Vermeesch, Beata Anna Nowakowska   +12 more
doaj   +1 more source

A theoretical base for non-invasive prenatal paternity testing

Forensic Science International, 2023
There is an increasing demand for prenatal paternity testing in the forensic applications, which identify biological fathers before the birth of children. Currently, one of the most effective and safe Non-Invasive Prenatal Paternity Testing (NIPPT) methods is high-throughput Next-Generation Sequencing (NGS)-based SNP genotyping of cell-free DNA in ...
Shengjie Gao, Bowen Li, Likai Mao, Wenfeng Wang, Dan Zou, Jianchao Zheng, Mi Zhou, Simin Yu, Feixue Zheng, Ye Yin, Shi Qiang Liu, Huanming Yang, Hongqi Wang   +12 more
openaire   +2 more sources

Analysis of the accuracy of Z-scores of non-invasive prenatal testing for fetal Trisomies 13, 18, and 21 that employs the ion proton semiconductor sequencing platform

Molecular Cytogenetics, 2018
Background Non-invasive prenatal testing (NIPT) is frequently being used to screen for trisomies 13, 18 and 21 for prenatal diagnosis. However, NIPT performs poorly when compared with invasive testing and thus should not be used to diagnose trisomies ...
Yuan Tian, Linlin Zhang, Weifang Tian, Jinshuang Gao, Liting Jia, Shihong Cui   +5 more
doaj   +1 more source

Non-Invasive Prenatal Testing beyond Trisomies

Journal of Medicine and Life, 2019
The last decade has seen incredible advances in the genetic era, in next-generation sequencing of cell-free DNA in the maternal plasma, detecting abnormal fetal chromosomes. Non-invasive prenatal testing (NIPT) has showed increased sensitivity and specificity for Down syndrome superior to any other screening test.
Suciu, Ioan Dumitru, Toader, Oana Daniela, Galeva, Slavyana, Pop, Lucian   +3 more
openaire   +2 more sources

The continuing saga of patents and non‐invasive prenatal testing [PDF]

Prenatal Diagnosis, 2019
AbstractObjectiveThis paper examines the Intellectual Property (IP) landscape for non‐invasive prenatal testing (NIPT) in three key regions: the United States; Europe, with particular focus on the United Kingdom; and Australia.MethodWe explore the patent law issues against the commercial and healthcare environment in these regions and consider the ...
Naomi Hawkins, Dianne Nicol, Subhashini Chandrasekharan, Robert Cook‐Deegan   +3 more
openaire   +3 more sources