Results 81 to 90 of about 1,282,521 (243)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Previsão Não-linear de Retornos na BOVESPA: Volume Negociado em um Modelo Auto-Regressivo de Transição Suave [PDF]

RAC: Revista de Administração Contemporânea, 2010
In this study, the predictive power of a logistic smooth transition auto regression model (LSTAR) in generating statistically significant returns is evaluated when the transition variable is trading volume and the lagged return itself, for the São Paulo ...
Robert Aldo Iquiapaza, Aureliano Angel Bressan, Hudson Fernandes Amaral   +2 more
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Comparative Study of Non‐Linear Car Following Models in Real‐Driving Scenarios

IET Intelligent Transport Systems
Car following models (CFMs) are the most prominent microscopic traffic flow models that capture the follower behaviour through detailed representation of leader–follower interactions.
Ranganatha Belagumba Ramachandra, Bidisha Ghosh, Vikram Pakrashi, Salissou Moutari, Timilehin Opeyemi Alakoya   +4 more
doaj   +1 more source

A Robust Non-Gaussian Data Assimilation Method for Highly Non-Linear Models

Atmosphere, 2018
In this paper, we propose an efficient EnKF implementation for non-Gaussian data assimilation based on Gaussian Mixture Models and Markov-Chain-Monte-Carlo (MCMC) methods.
Elias D. Nino-Ruiz, Haiyan Cheng, Rolando Beltran   +2 more
doaj   +1 more source

(Non) Linear Regression Modeling [PDF]

, 2011
We will study causal relationships of a known form between random variables. Given a model, we distinguish one or more dependent (endogenous) variables \(\mathbf{Y} = ({Y }_{1},\ldots,{Y }_{l}),l \in\mathbb{N}\), which are explained by a model, and independent (exogenous, explanatory) variables \(\mathbf{X} = ({X}_{1},\ldots,{X}_{p}),p \in\mathbb{N}\),
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Non-linear models of species' responses to environmental and spatial gradients. [PDF]

Ecol Lett, 2022
Anderson MJ, Walsh DCI, Sweatman WL, Punnett AJ.   +3 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source