Results 81 to 90 of about 223,220 (289)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Dermoscopy of skin metastases in advanced cancer—systemic (visceral, hematologic) and cutaneous

Frontiers in Medicine
IntroductionSkin metastases arise in 10% of cancer patients, but standardized dermoscopy diagnostic criteria for skin metastases remain poor. This study's objective was to analyze the dermoscopy features of skin metastases from advanced systemic and ...
Olga Simionescu, Olga Simionescu, Marian Petrică, Marian Petrică, Alina Mariana Avram, Alina Mariana Avram, Mariana Costache, Mariana Costache, Lucian G. Scurtu, Lucian G. Scurtu, Sorin Ioan Tudorache, Polixenia Georgeta Iorga, Polixenia Georgeta Iorga, Mariana Grigore, Mariana Grigore   +14 more
doaj   +1 more source

Skin cancer concerns particular to women

International Journal of Women's Dermatology, 2017
Background: Skin cancer has reached epidemic proportions, with more new cases diagnosed annually than the combined incidence of cancers of the breast, prostate, lung, and colon.
Z. Al-Dujaili, M. Henry, A.S. Dorizas, N.S. Sadick   +3 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Plesiotherapy for non-melanoma skin cancer: Innovating to overcome!

Indian Journal of Dermatology, 2010
Background: The non-surgical management of non-melanoma skin cancers is an area requiring clinical investigation. Radiotherapy has a role in treatment for a defined subset of patients.
Ray Amitabh, Basu Ayan, Deb Asit, Aich Ranen, Biswas Litan, Pal J   +5 more
doaj  

Skin cancer concerns particular to women

International Journal of Women's Dermatology, 2015
Background: Skin cancer has reached epidemic proportions, with more new cases diagnosed annually than the combined incidence of cancers of the breast, prostate, lung, and colon.
Z. Al-Dujaili, M. Henry, A.S. Dorizas, N.S. Sadick   +3 more
doaj   +1 more source

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]

, 2014
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
A Boucharaba, AD Mackenzie Ross, AJ Houben, AJ Muinonen-Martin, AJ Snider, AL Parrill, AM Algra, Andre Levchenko, Andrew J. Muinonen-Martin, C Carmona-Fontaine, C Scherber, C Zhao, CK Griffith, CM Balch, Colin Lindsay, D Dankort, D Zicha, D Zicha, David A. Knecht, Dorothy C. Bennett, Douwe M. Veltman, E Dona, E Lee, E Sierko, E Theveneau, Elizabeth Smethurst, ET Roussos, F Wach, G Tigyi, G Valentin, G Venkiteswaran, Gabriela Kalna, GL Garcia, J Condeelis, J Condeelis, J Murata, J Sleeman, J Wyckoff, JD Pedelacq, JM Haugh, JP Sleeman, JT Price, K Bandoh, K Jalink, Laura M. Machesky, M Abercrombie, M Gotoh, M Herlyn, M Jongsma, M Zaki, Michael J. O. Wakelam, MJ Payette, N Aaltonen, Olivia Susanto, Owen J. Sansom, P Berens, P Timpson, PN Devreotes, Qifeng Zhang, RA Sturm, Robert H. Insall, Robert Herd, Robert Jones, RR Langley, S Kuriyama, S Toetsch, S Toyozawa, SA Jordan, SH Zigmond, SH Zigmond, SK Hughes-Alford, W Wang, William J. Faller   +72 more
core   +3 more sources

Silibinin and non-melanoma skin cancers

Journal of Traditional and Complementary Medicine, 2020
Skin is the largest human organ that shields the inner body from contact with xenobiotic and genotoxic agents, and in this process, the skin's cellular genome faces continuous stress due to direct exposure to these noxious factors. Accumulation of genetic stress results in genomic alterations leading to undesirable gene or protein alteration/expression
Ram Raj Prasad, Sandeep Paudel, Komal Raina, Rajesh Agarwal   +3 more
openaire   +3 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Novel nano-biosensors for life science systems and their applications in early, accurate, and non-invasive melanoma and other types of cancer detection [PDF]

, 2007
Melanoma (the 5th and 6th most common cancer in Caucasian males and females, respectively), is the most severe form of skin cancer, which is often fatal if recognized in its advanced stage.
Bockrath, Marc, Kierk, Isabella, Landi, Maria   +2 more
core   +1 more source