Results 101 to 110 of about 223,220 (289)

Overview of skin cancer types and prevalence rates across continents

Cancer Pathogenesis and Therapy
Skin cancer is one of the most prevalent cancers in the world, and its incidence and mortality rates are increasing continuously, mostly in regions with white-skinned inhabitants. The types of skin cancer vary in their origin and clinical appearances and
Amdad Hossain Roky, Mohammed Murshedul Islam, Abu Mohammed Fuad Ahasan, Md Saqline Mostaq, Md Zihad Mahmud, Mohammad Nurul Amin, Md Ashiq Mahmud   +6 more
doaj   +1 more source

HLA and skin cancer HLA e câncer de pele

Anais Brasileiros de Dermatologia, 2012
Skin cancer - melanoma and non melanoma - are common neoplasm with rising incidence over the last decades. It is an important public health problem. Its pathogenesis is not completely understood and the same happens with the genetic factors involved. The
Renan Rangel Bonamigo, André Vicente Esteves de Carvalho, Vanessa Raquel Zaleski Sebastiani, Cristina Martino da Silva, Angela Caroline de Zorzi Pinto   +4 more
doaj   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Skin in the game: epidemiology analysis of skin cancer in rural Western Victoria

Rural and Remote Health
Introduction: The aim of this clinical review was to evaluate the number and types of skin cancer excised by GPs in a rural clinic in South West Victoria, Australia, and analyse the number needed to treat (NNT, a common metric for evaluating skin ...
Tori Dopheide, Jessica Feeney, Joshua Eaton, Jessica Beattie, Rizwan Jaipurwala, Lara Fuller, Leesa Walker   +6 more
doaj   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Fohotodermatoses and Skin Cancer [PDF]

, 2011
Preface Skin cancer is one of the most common types of tumors in Western countries. In the United States only, more than one million people are diagnosed with skin cancer each year.
Annunziata Raimondo, BALATO, ANNA, BALATO, NICOLA, Martina Mattii, MONFRECOLA, GIUSEPPE, Serena Lembo   +5 more
core  

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Skin Cancer Among Patients at a Major University Hospital in Saudi Arabia: A Retrospective, Single-Center Study

Clinical, Cosmetic and Investigational Dermatology
Abdossalam M Madkhali,1 Ghaida A Almarshoud,2 Layan F Alsanad,2 Rima Omar Alomar,2 Alia A Zawawi,2 Saud F Alrsheed,2 Sarah R Alaidarous,2 Bushra Alraddadi,3,4 Basel Bandar Almalki,4 Abdulaziz Madani4 1Department of Medicine, Oncology, Hematology and ...
Madkhali AM, Almarshoud GA, Alsanad LF, Alomar RO, Zawawi AA, Alrsheed SF, Alaidarous SR, Alraddadi B, Almalki BB, Madani A   +9 more
doaj  

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

The risk of skin cancer in women who carry BRCA1 or BRCA2 mutations

Hereditary Cancer in Clinical Practice
Background It has not been clearly established if skin cancer or melanoma are manifestations of BRCA1 or BRCA2 mutation carrier status. Estimating the risk of skin cancer is an important step towards developing screening recommendations.
Steven A. Narod, Kelly Metcalfe, Amy Finch, An-Wen Chan, Susan Randall Armel, Amber Aeilts, Andrea Eisen, Beth Karlan, Louise Bordeleau, Nadine Tung, William D. Foulkes, Susan L. Neuhausen, Charis Eng, Olufunmilayo Olopade, Dana Zakalik, Fergus Couch, Carey Cullinane, Tuya Pal, Ping Sun, Joanne Kotsopoulos, the Hereditary Breast Cancer Clinical Research Group   +20 more
doaj   +1 more source