Results 71 to 80 of about 40,360 (291)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

دراسة تاثير المتضمنات اللامعدنية على مطروقات الفولاذ واطئ التسبيك

Journal of Engineering and Sustainable Development, 2022
The non-metallic inclusions can be found in steel as a result of existence of oxygen and sulpher in form of oxides and sulphides which they have relative low solubility.
علي حسين عتيوي, ستار عبود عباس, صباح عجيب كاصد   +2 more
doaj  

Application of Photoelasticy for Study of Lamellar Cracks. [PDF]

, 2013
In rolled sheets, non–metallic inclusions are distributed along the thickness of the sheet as narrow lines running parallel to the rolling direction. Such inclusions are the nuclei of lamellar cracks.
Jaroniek, Mieczysław, Niezgodziński, Tadeusz   +1 more
core  

Optomagnetic composite medium with conducting nanoelements

, 2002
A new type of metal-dielectric composites has been proposed that is characterised by a resonance-like behaviour of the effective permeability in the infrared and visible spectral ranges. This material can be referred to as optomagnetic medium.
A. Fert, A. N. Grigorenko, A. N. Lagarkov, A. N. Lagarkov, A. N. Lagarkov, A. P. Vinogradov, D. P. Makhnovskiy, D. P. Makhnovskiy, D. P. Makhnovskiy, D. R. Smith, D. R. Smith, F. Mariotte, G. A. Niklasson, J. B. Pendry, J. B. Pendry, J. B. Pendry, J. Rothman, K. K. Bardhan, K. K. Mei, K. Liu, K. Liu, L. V. Panina, L. V. Panina, M. M. I. Saadoun, M. Notomi, P. M. Duxbury, R. A. Shelby, R. J. Gehr, V. G. Veselago, V. M. Shalaev, V. M. Shalaev, Y. S. Yeh   +31 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Rotating bending fatigue behavior of medium carbon Cr and W nitriding bearing steel

Journal of Hebei University of Science and Technology, 2018
Aiming at the problem that the failure mode of bearing steels is mainly fatigue failure, RBF (rotating bending fatigue) test of medium carbon Cr and W nitriding bearing steel and analysis are conducted for the medium carbon Cr and W nitriding bearing ...
Shichao CHENG, Huijun WEI, Shiqing SUN, Song WANG, Ruiyang WANG, Boshuai CUI, Nianlun WEI   +6 more
doaj   +1 more source

Effect of non-metallic inclusions on cleavage fracture

Materials Science and Technology, 1986
Abstract The effect of non-metallic inclusions on cleavage in wrought steel has been studied using a resulphurized mild steel. The cleavage fracture stress was measured at –196°C and found to exhibit an orientation dependence which is attributed to the morphology of the inclusions.
T. J. Baker, F. P. L. Kavishe, J. Wilson
openaire   +2 more sources

Purcell effect at metal-insulator transitions

, 2016
We investigate the spontaneous emission rate of a two-level quantum emitter next to a composite medium made of randomly distributed metallic inclusions embedded in a dielectric host matrix.
Farina, C., Kort-Kamp, W. J. M, Pinheiro, F. A., Rosa, F. S. S., Szilard, D.   +4 more
core   +1 more source

Superlens made of a metamaterial with extreme effective parameters [PDF]

, 2008
We propose a superlens formed by an ultra-dense array of crossed metallic wires. It is demonstrated that due to the anomalous interaction between crossed wires, the structured substrate is characterized by an anomalously high index of refraction and ...
Costa, J. R., Fernandes, C. A., Silveirinha, M. G.   +2 more
core   +2 more sources