Results 31 to 40 of about 186,870 (267)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Blasting ore size detection based on efficient dehazing network and multi-dimensional feature fusion

Scientific Reports
Ore particle size distribution is an important metric for evaluating blasting outcomes and affects the energy consumption of ore crushing equipment. Faced with dense accumulation of ore, nonuniform size distributions, dust occlusion, and target loss due ...
Pingfeng Li, Shoudong Xie, Wanzhong Zhang, Deming Chen, Sheng Peng, Weibin Fang, Dehao Zeng   +6 more
doaj   +1 more source

Substantiation of ways for rational use of deep pit technogenic resources

Горные науки и технологии, 2018
The purpose of the paper is to solve the scientific and practical problem of the rational use of technogenic resources in open-pit mining as exemplified by deep Muruntau open pit. Overview of the studies in this area is given.
N. P. Snitka, B. R. Raimjanov, R. Sh. Naimova   +2 more
doaj   +1 more source

Soil mesoarthropods in areas of coal mining under environmental recovery [PDF]

Pesquisa Agropecuária Brasileira, 2017
: The objective of this work was to evaluate the soil mesofauna composition in non-mining and in mining areas under environmental recovery with native vegetation and forest planting, in a coalmine in Southern Brazil.
Dayanna do Nascimento Machado, Ervandil Corrêa Costa, Leandra Pedron   +2 more
doaj   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Real-time monitoring and prediction of remote operator fatigue in plateau deep mining based on dynamic Bayesian networks

Scientific Reports
Fatigue can cause human error, which is the main cause of accidents. In this study, the dynamic fatigue recognition of unmanned electric locomotive operators under high-altitude, cold and low oxygen conditions was studied by combining physiological ...
Shoukun Chen, Liya Pan, Kaili Xu, Xijian Li, Yujun Zuo, Zheng Zhou, Bin Li, Zhangyin Dai, Zhengrong Li   +8 more
doaj   +1 more source

Adsorption of phosphate by cancrinite in red mud: a first-principles study

Materials Research Express, 2022
Cancrinite is the key substance that affects the adsorption effect of phosphate from red mud(RM) . Therefore, cancrinite in RM was modified to improve its adsorption performance. Based on density functional theory(DTF), this paper optimized the structure
Zhou Xiaotian, Longjiang Li, Qiu Yueqin, Liu Wanshuang   +3 more
doaj   +1 more source

Research on Non-Pillar Coal Mining for Thick and Hard Conglomerate Roof

Energies, 2021
This article introduces a new non-pillar coal mining technology (i.e., Gob-side Entry Retaining by Roof Cutting (GERRC)) under the condition of thick and hard roofs.
Xiaoyu Liu, Manchao He, Jiong Wang, Zimin Ma   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effect of Sulfuric Acid Corrosion on Flotation Performance of Calcite by Changing Surface Roughness

Molecules
Surface roughness is a crucial factor that affects the flotation performance of minerals. In this study, the effect of sulfuric acid corrosion on the surface roughness of calcite flotation was investigated through microflotation tests, scanning electron ...
Dingquan Xing, Ruofan Sun, Shuai Ma, Heping Wen, Zhongchi Wang, Jiushuai Deng   +5 more
doaj   +1 more source