Results 51 to 60 of about 7,664,425 (315)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Simulation of solute transport behaviors in saturated karst aquifer system
Scientific Reports, 2021 The karst development makes aquifer have strong anisotropy and heterogeneity. In order to reveal the characteristics of solute transport in the karst fissure–conduit aquifer system, this study presents a physical model of fissure–conduit in laboratory ...
Xuewei Chu, Hanghang Ding, Xuemei Zhang
doaj +1 more source
Rock and Soil Mechanics, 2021 In order to explore the impact of moisture on the mechanical properties of coal, the triaxial compression tests of raw coal with different moisture contents are carried out by using the triaxial servo-controlled seepage equipment for thermal-hydro ...
LI Bo-bo +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Scientific ReportsThis study investigates the internal geometry of the granite block rows in the King’s Chamber (KC) of the Great Pyramid of Giza using Non-destructive testing (NDT) with ultrasonic testing (UST) using shear wave echo arrays.
Benedikt Maier +9 more
doaj +1 more source
Research and dissemination : support for communities affected by mining in Canada and around the globe (2009-2010) [PDF]
, 2010 MiningWatch was created to strengthen and forge global linkages to support communities affected by mining and to bring about reforms that will promote responsible mining practices while providing redress for existing and past damages.
Mining Watch Canada
core
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Effect of Metal Cations on Hydration of Montmorillonite and its Mechanism
Kuangchan zonghe liyongThis is an article in the field of mining engineering. Montmorillonite is a kind of clay mineral which has significant impact on the sedimentation of coal slime water.
Yongli YANG, Wei CHENG, Wenhao HUANG
doaj +1 more source
Silicosis in non-mining industry on the Witwatersrand.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1988 Silicosis outside the mines in South Africa has received little legislative or public attention. Between 1972 and 1986 217 such cases were seen at the National Centre for Occupational Health clinic, including 46 cases of progressive massive fibrosis. The relatively high proportion of cases of progressive massive fibrosis (21%), of patients less than or
R I, Ehrlich, D, Rees, A B, Zwi
openaire +1 more source