Results 261 to 270 of about 12,797,283 (292)

Parkinson’s disease: a review of non-motor symptoms

Expert Review of Neurotherapeutics, 2015
Parkinson's disease (PD) is a neurodegenerative disorder resulting from degeneration of the substantia nigra and the dopaminergic nigrostriatal pathway. Most treatments are geared toward the management and relief of motor symptoms in Parkinson's patients; however, as the disease progresses, various complications can be observed. Non-motor symptoms (NMS)
Abdul Qayyum, Rana, Uzma S, Ahmed, Zishan M, Chaudry, Sai, Vasan   +3 more
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Overlooked non-motor symptoms in myasthenia gravis

Journal of Neurology, Neurosurgery & Psychiatry, 2012
Patients with myasthenia gravis (MG) may have various non-motor symptoms in addition to fatigability and weakness of skeletal muscles. Thymomas contain abundant immature thymocytes and developing CD4 and CD8 T cells. Thymomas are found in 15-25% of patients with MG and are associated with severe symptoms. We suggest that non-motor symptoms are based on
Shigeaki, Suzuki, Kimiaki, Utsugisawa, Norihiro, Suzuki   +2 more
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The heterogeneity of non-motor symptoms of Parkinson’s disease

Neurological Sciences, 2014
In addition to motor symptoms, patients with Parkinson's disease (PD) may experience non-motor symptoms (NMS), more often with more advanced disease stage. However, the clinical feature of the NMS and potential risk factors that affect NMS in idiopathic PD patients remain unclear. 493 PD patients diagnosed with PD via the UK.
Ning, Zhang, Weiguo, Liu, Min, Ye, Alexander D, Cohen, Yingdong, Zhang   +4 more
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Quantitation of non‐motor symptoms in Parkinson’s disease

European Journal of Neurology, 2008
Background:  Disabling non‐motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease.
Chaudhuri, K Ray, Martinez-Martin, P
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Neuropathobiology of non-motor symptoms in Parkinson disease

Journal of Neural Transmission, 2015
Parkinson disease (PD) is a multisystem disorder associated with α-synuclein aggregates throughout the central, autonomic, and peripheral nervous system, clinically characterized by motor and non-motor (NM) symptoms. The NMS in PD, many of which antedating motor dysfunction and representing a preclinical phase spanning 20 or more years, are linked to ...
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Brainstem pathology and non-motor symptoms in PD

Journal of the Neurological Sciences, 2010
Parkinson's disease (PD) is considered a multisystem disorder involving dopaminergic, noradrenergic, serotoninergic, and cholinergic systems, characterized by motor and non-motor symptoms. The causes of the non-motor symptoms in PD are multifactorial and unlikely to be explained by single lesions.
Lea Tenenholz, Grinberg, Udo, Rueb, Ana Tereza di Lorenzo, Alho, Helmut, Heinsen   +3 more
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Sarcopenia as a non-motor symptom of Parkinson’s disease

S.S. Korsakov Journal of Neurology and Psychiatry
Sarcopenia is a progressive generalized skeletal muscle disease that is accompanied by an accelerated loss of muscle mass and function, affecting the quality of life and the ability to perform self-care. The prevalence of sarcopenia in the world today ranges from 10 to 25%, which represents a certain danger as it is a prognostic factor for possible ...
N.G. Zhukova, M.V. Matveeva, P.E. Kazantseva, Iu.G. Samoilova, A.Ya. Masenko, O.V. Gaponova, I.A. Zhukova   +6 more
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Non-motor symptoms in Parkinson's disease: An explorative network study

Parkinsonism & Related Disorders, 2019
Research on the association between non-motor symptoms (NMS) of Parkinson's disease (PD) and patients' quality of life (QoL) has given insight into the burden of NMS. Most studies investigate NMS by assessing the contribution of individual symptoms to QoL.
Engels, Gwenda, Douw, L., Kerst, Yvonne, Weinstein, H., Scherder, Erik, Vlaar, Annemarie   +5 more
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Non-motor Symptoms and Treatments in Parkinson’s Disease

Neurologic Clinics
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms. The non-motor features may precede the onset of motor symptoms and occur throughout all stages of PD. The non-motor symptoms reflect multisystem involvement of the central and peripheral nervous systems, multiple neurotransmitters, and multiple ...
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Non-motor symptom subtypes in early Parkinson's disease

Parkinsonism & Related Disorders
Parkinson's disease (PD) is a clinically heterogeneous disorder characterized by a broad spectrum of non-motor symptoms. Defining non-motor subtypes may help clarify early pathophysiological mechanisms, predict disease progression, and guide personalized care.To identify non-motor PD subtypes through an unsupervised approach, evaluate their consistency
Vittorio Velucci, Giovanni Iliceto, Barbara Vitucci, Sarah Idrissi, Giammarco Milella, Marcello Mario Mascia, Antonella Muroni, Giovanni Defazio   +7 more
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