Results 31 to 40 of about 11,745,756 (213)

Low-molecular synthetic peptides with non-narcotic type of analgesia: comparative study and mechanism of analgesic activity

Molecular Pain, 2019
The group of synthetic low-molecular peptides exhibiting profound analgesic activity was developed by modifying the salmon calcitonin molecule fragment sCT 16-21 , which retains the previously reported analgesic activity of the full-sized molecule.
Arkady M Kotin, Maksim O Emelyanov, Oleg A Kotin   +2 more
doaj   +1 more source

Anthelmintic and analgesic activities of different solvent fractions of crude methanolic extract of Baccaurea ramiflora (Lour.) fruit peels and seeds with molecular docking analysis [PDF]

Journal of HerbMed Pharmacology
Introduction: Baccaurea ramiflora Lour, locally known as Latkan, is a popular fruit in Bangladesh used for its anthelmintic and analgesic activities. This study aimed to compare the anthelmintic and analgesic activities of different solvent fractions of ...
Mantasha Tabassum, Najneen Ahmed, Joynta Majumder, Nazifa Tabassum, Md. Ashraful Islam   +4 more
doaj   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

The effect on post-operative pain of intravenous clonidine given before induction of anaesthesia

Indian Journal of Anaesthesia, 2012
Background: Treatment of acute post-thoracotomy pain is particularly important not only to keep the patient comfortable but also to minimize pulmonary complications.
Aloka Samantaray, Mangu Hanumantha Rao, Abha Chandra   +2 more
doaj   +1 more source

The Role of Nitrous Oxide (“Laughing Gas”) in DUID Cases and Its Impact on Driving Fitness

Drug Testing and Analysis, EarlyView.
A total number of 39 cases of driving under the influence of nitrous oxide were investigated. Plasma concentrations of 0.22 to 17 mL/L (median:3.7 mL/L) were measured in blood samples withdrawn 38 to 144 min (median: 85 min) after control via Headspace‐GC–MS.
L. Lucuta, P. Stach, J. Hose, H. Andresen‐Streichert, M. Juebner   +4 more
wiley   +1 more source

Transport of narcotic analgesics by choroid plexus and kidney tissue in vitro [PDF]

, 1967
Radioactive narcotic analgesics, including morphine, dihydromorphine, nalorphine, codeine, levorphan, dextrorphan, and l-methorphan were accumulated against an apparent concentration gradient in pieces of rabbit and dog choroid plexus and in slices of ...
Hug, Carl C. Jr., Carl C. Hug
core   +1 more source

Ultrasound‐Guided Fasciotomy for Chronic Exertional Compartment Syndrome: A Case Report With Long‐Term Sonographic Outcomes

Journal of Clinical Ultrasound, EarlyView.
First report of the long‐term sonographic appearance after ultrasound‐guided fasciotomy for chronic exertional compartment syndrome. Six‐month ultrasound demonstrated persistent fascial separation associated with excellent clinical outcomes. ABSTRACT We report the case of a 38‐year‐old recreational female runner with anterior and lateral chronic ...
Alexandre Lavigne, Brennan J. Boettcher, Michael Khadavi   +2 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

TORPEDO: Prospective, double blind, randomized clinical trial comparing the use of Ketorolac verse placebo during live donor nephrectomy for kidney transplant

Transplantation Reports, 2017
The aim of this pilot study was to determine if the use of Ketorolac for donor nephrectomies could decrease the use of narcotics. Methods: This is a prospective, double blind, randomized trial involving patients undergoing nephrectomy for live donor ...
Jeffrey Campsen, Tyler Call, Heather F. Thiesset, Alec Rosales, Robin D. Kim   +4 more
doaj   +1 more source

Regenerative Peripheral Nerve Interface (RPNI) Surgery for Naturalistic Prosthetic Control

Muscle &Nerve, EarlyView.
ABSTRACT Loss of limb function remains a significant public health challenge affecting millions of people worldwide, causing high rates of disability, unemployment, and chronic pain. Current neuroprosthetic devices are limited by unintuitive control and poor long‐term embodiment.
Ahneesh J. Mohanty, Yucheng Tian, Theodore A. Kung, Cynthia A. Chestek, Alex K. Vaskov, Deanna H. Gates, Alison K. Snyder‐Warwick, Paul S. Cederna   +7 more
wiley   +1 more source