Results 51 to 60 of about 11,033 (182)

Low-molecular synthetic peptides with non-narcotic type of analgesia: comparative study and mechanism of analgesic activity

Molecular Pain, 2019
The group of synthetic low-molecular peptides exhibiting profound analgesic activity was developed by modifying the salmon calcitonin molecule fragment sCT 16-21 , which retains the previously reported analgesic activity of the full-sized molecule.
Arkady M Kotin, Maksim O Emelyanov, Oleg A Kotin   +2 more
doaj   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

THE STUDY OF EFFECTS OF THE INTRANASAL DEXMEDETOMIDINE ADMINISTRATION ON PAIN SENSITIVITY

Разработка и регистрация лекарственных средств, 2019
The development of new antinociceptive agents and new approaches to pain relief based on potent non-narcotic analgesics is one of the most in demand and urgent directions of modern pharmacology.
O. I. Rudko, E. A. Klimov, V. V. Sobolev, A. V. Sosnov, K. A. Rufanov, F. M. Semchenko   +5 more
doaj  

Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim‐Sulfamethoxazole Acute Respiratory Distress Syndrome

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an approach to prioritize identification and validation of a rare ADR to trimethoprim‐sulfamethoxazole causing ...
Keith Feldman, Jenna O. Miller, Katherine Doane, Laura Loftis, James W. Antoon, Kevin J. Downes, Jennifer L. Goldman   +6 more
wiley   +1 more source

Podocyte mPGES‐2 Determines Renal Aging and Contributes to Senile Osteoporosis

Aging Cell, Volume 25, Issue 7, July 2026.
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Dandan Zhong, Chang Hao, Mengyue Li, Jing Liu, Zheng Xu, Jianteng Zhou, Lu Zhao, Siyu Ni, Zhenchao Hu, Yue Sun, Yingying Zou, Dong Sun, Hao Guo, Zhanjun Jia, Dong Guo, Jun‐Li Cao, Ying Sun   +16 more
wiley   +1 more source

SELECTION CRITERIA OF COMPOUNDS FOR DEVELOPMENT OF HIGH-POTENT ANALGESICS AND OTHER CNS DRUGS

Разработка и регистрация лекарственных средств, 2019
The global opioid crisis requires a paradigm shift in medical use of opioids, the development of methodology to reduce illicit drug use, and development of drug addiction treatment and antidotes.
A. V. Sosnov, F. M. Semchenko, V. N. Tohmahchi, A. A. Sosnova, M. I. Vlasov, A. S. Radilov, D. V. Krivorotov   +6 more
doaj  

SYNERGISM OF THE ANALGESIC ACTIVITY OF METAMIZOLE SODIUM WITH KETAMINE AND DEXMEDETOMIDINE IN MULTIMODAL ANALGESIA IN A MODEL OF ACUTE VISCERAL PAIN

Клінічна та профілактична медицина
Introduction. Multimodal analgesia is a cornerstone of opioid-sparing strategies for acute pain management. Metamizole is a widely used non-opioid analgesic with combined peripheral and central mechanisms; however, its potentiation by central adjuvants ...
Mariia V. Matvieienko, Mykola O. Chyzh, Fedir V. Hladkykh, Olha V. Basarab, Madona O. Gogiya   +4 more
doaj   +1 more source

CT-guided Celiac Plexus Neurolysis in the Management of Severe Upper Abdominal Pain

Ukrainian Neurosurgical Journal, 2020
Abdominal pain is a significant problem in patients with malignant tumors of the abdominal cavity, which dramatically affects the quality of life and survival. Chronic pain is experienced by about half of all cancer patients and more than 70  %
Aleksey A. Eroshkin, Dmytro M. Romanukha
doaj   +1 more source

The Interplay Between Sleep Disturbance, Glymphatic Dysfunction and Altered Brain Networks in Internet Gaming Disorder: A Multimodal Neuroimaging Study

Addiction Biology, Volume 31, Issue 7, July 2026.
This multimodal neuroimaging study explores the neurobiological mechanisms of Internet Gaming Disorder (IGD) by integrating DTI–ALPS and resting–state functional connectivity. The findings reveal that individuals with IGD exhibit reduced glymphatic system–related function, which is significantly associated with poorer subjective sleep quality ...
Jiawen Tian, Hui Zhang, Xinyu Wang, Hongyu Zhang, Longyao Ma, Bohui Mei, Mengzhe Zhang, Yan Lang, Yarui Wei, Shaoqiang Han, Qingqing Lv, Yong Zhang   +11 more
wiley   +1 more source

Mirogabalin for Neuropathic Pain: A Review of Non-Opioid Pharmacotherapy with Insights from Japan

Future Pharmacology
Background and Aim: Neuropathic pain leads to a significant deterioration in health-related quality of life (HRQOL). Treating neuromusculoskeletal pain is especially important to prevent and improve physical frailty and the locomotive syndrome.
Mizuho Sumitani, Takamichi Kogure, Hiroaki Abe, Rikuhei Tsuchida, Reo Inoue, Masahiko Sumitani   +5 more
doaj   +1 more source