Results 71 to 80 of about 14,760 (255)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Robust Semi-Supervised Non-Negative Matrix Factorization With Structured Normalization

IEEE Access, 2019
Non-negative matrix factorization (NMF) approximates a non-negative data matrix with the product of two low-rank non-negative matrices by minimizing the cost of such approximation.
Liujing Wang, Naiyang Guan, Dianxi Shi, Zunlin Fan, Longfei Su   +4 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Muscle Synergy during Wrist Movements Based on Non-Negative Tucker Decomposition

Sensors
Modular control of the muscle, which is called muscle synergy, simplifies control of the movement by the central nervous system. The purpose of this study was to explore the synergy in both the frequency and movement domains based on the non-negative ...
Xiaoling Chen, Yange Feng, Qingya Chang, Jinxu Yu, Jie Chen, Ping Xie   +5 more
doaj   +1 more source

A New Feature Extraction and Recognition Method for Microexpression Based on Local Non-negative Matrix Factorization

Frontiers in Neurorobotics, 2020
Microexpression is usually characterized by short duration and small action range, and the existing general expression recognition algorithms do not work well for microexpression.
Junli Gao, Huajun Chen, Xiaohua Zhang, Jing Guo, Wenyu Liang   +4 more
doaj   +1 more source

On Affine Non-Negative Matrix Factorization [PDF]

2007 IEEE International Conference on Acoustics, Speech and Signal Processing - ICASSP '07, 2007
We generalize the non-negative matrix factorization (NMF) generative model to incorporate an explicit offset. Multiplicative estimation algorithms are provided for the resulting sparse affine NMF model. We show that the affine model has improved uniqueness properties and leads to more accurate identification of mixing and sources.
Hans Laurberg, Lars Kai Hansen
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Non-negative Matrix Factorization on Manifold [PDF]

2008 Eighth IEEE International Conference on Data Mining, 2008
Recently non-negative matrix factorization (NMF) has received a lot of attentions in information retrieval, computer vision and pattern recognition. NMF aims to find two non-negative matrices whose product can well approximate the original matrix. The sizes of these two matrices are usually smaller than the original matrix. This results in a compressed
Deng Cai, Xiaofei He, Xiaoyun Wu, Jiawei Han   +3 more
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source