Results 71 to 80 of about 142,276 (359)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Semantic Non-Negative Matrix Factorization for Term Extraction

Big Data and Cognitive Computing
This study introduces an unsupervised term extraction approach that combines non-negative matrix factorization (NMF) with word embeddings. Inspired by a pioneering semantic NMF method that employs regularization to jointly optimize document–word and word–
Aliya Nugumanova, Almas Alzhanov, Aiganym Mansurova, Kamilla Rakhymbek, Yerzhan Baiburin   +4 more
doaj   +1 more source

Non Negative Matrix Factorization Clustering Capabilities; Application on Multivariate Image Segmentation [PDF]

Journal of Electrical and Electronics Engineering, 2009
The clustering capabilities of the Non Negative MatrixFactorization algorithm is studied. The basis images are consideredlike the data membership degree to a particular class.A hard clustering algorithm is easily derived based on theseimages.
Cosmin Lazar, Danielle Nuzillard, Patrice Billaudel, Sorin Curila   +3 more
doaj  

Infinite Non-Negative Matrix Factorization

, 2010
Publication in the conference proceedings of EUSIPCO, Aalborg, Denmark ...
Mørup, Morten, Schmidt, Mikkel
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Document Clustering Based On Max-Correntropy Non-Negative Matrix Factorization [PDF]

, 2014
Nonnegative matrix factorization (NMF) has been successfully applied to many areas for classification and clustering. Commonly-used NMF algorithms mainly target on minimizing the $l_2$ distance or Kullback-Leibler (KL) divergence, which may not be ...
Li, Le, Qin, Zhen, Xu, Yang, Yang, Jianjun, Zhang, Honggang   +4 more
core  

Multifrontal Non-negative Matrix Factorization

, 2020
Non-negative matrix factorization (Nmf) is an important tool in high-performance large scale data analytics with applications ranging from community detection, recommender system, feature detection and linear and non-linear unmixing. While traditional Nmf works well when the data set is relatively dense, however, it may not extract sufficient structure
Piyush Sao, Ramakrishnan Kannan
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

KOMPRESI DAN PENGENALAN CITRA WAJAH DENGAN PENDEKATAN NON-NEGATIVE MATRIX FACTORIZATION [PDF]

, 2012
KOMPRESI DAN PENGENALAN CITRA WAJAH DENGAN PENDEKATAN NON-NEGATIVE MATRIX FACTORIZATION - Face recognition, kompresi, Non-negative Matrix Factorization, Principal Component Analysis, Eigenface, Computer ...
BENNY KURNIAWAN USODO, FICTOR, CITRA SENTOSA, LUKMAN, MEWLANDO, CHRISTIANTO   +2 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source