Results 51 to 60 of about 1,535 (215)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Non Negative Matrix Factorization Clustering Capabilities; Application on Multivariate Image Segmentation [PDF]
Journal of Electrical and Electronics Engineering, 2009 The clustering capabilities of the Non Negative MatrixFactorization algorithm is studied. The basis images are consideredlike the data membership degree to a particular class.A hard clustering algorithm is easily derived based on theseimages.
Cosmin Lazar +3 more
doaj
Hessian Regularization Based Factorization Algorithm Combining Multi-view and Non-negative Matrix [PDF]
Jisuanji gongcheng, 2017 Non-negative matrix does not consider the manifold of data when represents multi-view data,which results in the ineffective express of the data internal expression.In this paper,Hessian regularized Non-negative Matrix Factorization(NMF) is proposed.By ...
WANG Chaofeng,SHI Jun,WU Jinjie,ZHU Jie
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Binary Orthogonal Non-negative Matrix Factorization
, 2023 We propose a method for computing binary orthogonal non-negative matrix factorization (BONMF) for clustering and classification. The method is tested on several representative real-world data sets. The numerical results confirm that the method has improved accuracy compared to the related techniques.
Sajad Fathi Hafshejani +3 more
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Enforced Sparse Non-negative Matrix Factorization [PDF]
2016 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW), 2016 Non-negative matrix factorization (NMF) is a dimensionality reduction algorithm for data that can be represented as an undirected bipartite graph. It has become a common method for generating topic models of text data because it is known to produce good results, despite its relative simplicity of implementation and ease of computation.
Brendan Gavin +2 more
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source