Results 51 to 60 of about 16,408 (214)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Robust Hierarchical Learning for Non-Negative Matrix Factorization With Outliers
IEEE Access, 2019 Desirable properties of extensions of non-negative matrix factorization (NMF) include robustness in the presence of noises and outliers, ease of implementation, the guarantee of convergence, operation in an automatic fashion that trades off the balance ...
Yinan Li +4 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Frontiers in Neurorobotics, 2020 Microexpression is usually characterized by short duration and small action range, and the existing general expression recognition algorithms do not work well for microexpression.
Junli Gao +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Multi-Focus Image Fusion Based on WNMF and Focal Point Position Analysis
工程科学与技术, 2011 :In this paper, a multi-focus image fusion method based on the weighted non-negative matrix factorization is presented to improve image fusion method based on non-negative matrix factorization.
A Du Jian Hua
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
NeuroImage, 2020 In this work we use non-negative matrix factorization to identify patterns of microstructural variance in the human hippocampus. We utilize high-resolution structural and diffusion magnetic resonance imaging data from the Human Connectome Project to ...
Raihaan Patel +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Locally Constrained Non-Negative Matrix Factorization for Data Clustering
IEEE AccessSemi-supervised non-negative matrix factorization (NMF) has been widely used for clustering high-dimensional data, because a small amount of label information can effectively improve clustering performance. Nevertheless, most existing semi-supervised NMF
Xuzhu Shen, Jie Li
doaj +1 more source