Results 81 to 90 of about 57,158 (293)

Identification of ITPR1 gene as a novel target for hsa-miR-34b-5p in non-obstructive azoospermia: a Ca2+/apoptosis pathway cross-talk

Scientific Reports, 2023
MiR-34b-5p has been reported as a non-invasive diagnostic biomarker for infertility. However, no gene targets regulating the mechanism of cation of this miRNA are known.
Bahareh Maleki, Parastoo Modarres, Peyman Salehi, Sadeq Vallian   +3 more
semanticscholar   +1 more source

SPARK: A webserver for comprehensive search and analysis of testicular single‐cell transcriptomic data covering full lifecycle and pathology

iMetaOmics, EarlyView.
SPARK is an interactive platform hosting 189,232 human testicular single‐cell transcriptomes across normal and infertile conditions. It enables automated, code‐free analysis and visualization, providing a powerful resource to explore cellular and molecular dynamics in male reproduction and infertility.
Lina Cui, Xiaojian Lu, Hui Cai, Ziyan Zhuang, Yifei Guo, Qiaoling Jiang, Zhe Zhang, Hui Jiang, Xiaoyan Wang, Jingtao Guo   +9 more
wiley   +1 more source

Cut-off Value of Testosterone and FSH Level In Patient With Azoospermia [PDF]

, 2016
Follicle-stimulating hormone(FSH) and Testosterone are important for spermatogenesis. Increased serum FSH and decreased testosterone are related to abnormal spermatogenesis.
Basukarno, Ari, Birowo, Ponco, Rasyid, Nur   +2 more
core   +2 more sources

Chromosomal and molecular abnormalities in a group of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia attending an infertility service

International Brazilian Journal of Urology, 2011
PURPOSE: To determine the frequency of genetic alterations in a population of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia.
Fernanda A. Mafra, Denise M. Christofolini, Bianca Bianco, Marcello M. Gava, Sidney Glina, Sintia I. N. Belangero, Caio P. Barbosa   +6 more
doaj   +1 more source

Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermia

Cell Cycle, 2023
Spermatogenic arrest is a severe form of non-obstructive azoospermia (NOA), which occurs in 10–15% of infertile men. Interruption in spermatogenic progression at premeiotic, meiotic, or postmeiotic stage can lead to arrest in men with NOA. Recent studies
S. Ozturk
semanticscholar   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Search and identification of spermatozoa and spermatids in the ejaculate of non-obstructive azoospermic patients [PDF]

, 2005
OBJECTIVE: To search and to identify spermatozoa and spermatids, present in the ejaculate of non-obstructive azoospermic patients. MATERIALS AND METHODS: 27 patients, aged between 18 and 48 years, with initial diagnosis compatible with non-obstructive ...
Buttignol, Marcia H.p. [UNIFESP], Cedenho, Agnaldo Pereira [UNIFESP], Fraietta, Renato [UNIFESP], Ortiz, Valdemar [UNIFESP], Spaine, Deborah M. [UNIFESP], Srougi, Miguel [UNIFESP], Timm Jr, Odival [UNIFESP]   +6 more
core   +3 more sources

Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. [PDF]

, 2020
Male factor infertility is a problem in today's society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Behr, Rüdiger, Brehm, Ralph HJ, Distl, Ottmar, Hilbold, Erika, Hoedemaker, Martina, Jung, Klaus, Langeheine, Marion, Metzger, Julia, Rajkovic, Aleksandar, Rode, Kristina, Wilkening, Sandra   +10 more
core   +1 more source

Whole transcriptome analysis to identify non-coding RNA regulators and hub genes in sperm of non-obstructive azoospermia by microarray, single-cell RNA sequencing, weighted gene co-expression network analysis, and mRNA-miRNA-lncRNA interaction analysis

BMC Genomics
Background The issue of male fertility is becoming increasingly common due to genetic differences inherited over generations. Gene expression and evaluation of non-coding RNA (ncRNA), crucial for sperm development, are significant factors.
Danial Hashemi Karoii, Hossein Azizi, Thomas Skutella   +2 more
semanticscholar   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source