Results 101 to 110 of about 921,406 (312)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
A non-parametric investigation of risk premia
This paper investigates features of credit risk using non-parametric techniques, studying determinants of risk premia using a non-parametric term-structure model of the corporate spread. The model, which measures the extra return of defaultable corporate
Peroni, Chiara
core +3 more sources
Non-parametric correlation structures and their respective embeddings in predictive analysis
Discover Applied SciencesIn data analysis, there is a natural connection between correlation and visual analysis. Correlation analysis enables the identification of relationships between attribute pairs in multidimensional datasets, while visual data analysis focuses on ...
Adam Dudáš
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Alexandria Engineering JournalThe growing digital transformation has increased the need for effective intrusion detection systems. Traditional intrusion detection systems face challenges in accurately classifying complex patterns.
C. Rajathi, P. Rukmani
doaj +1 more source
GDP nowcasting with ragged-edge data : A semi-parametric modelling [PDF]
This papier formalizes the process of forecasting unbalanced monthly data sets in order to obtain robust nowcasts and forecasts of quarterly GDP growth rate through a semi-parametric modelling.
Patrick Rakotomarolahy +2 more
core
Parametric and Multiobjective Optimization with Applications in Finance [PDF]
, 2010 In this thesis parametric analysis for conic quadratic optimization problems is studied. In parametric analysis, which is often referred to as parametric optimization or parametric programming, a perturbation parameter is introduced into the ...
Romanko, Oleksandr
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source