Results 121 to 130 of about 30,589,948 (306)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The contribution of work and non-work stressors to common mental disorders in the 2007 Adult Psychiatric Morbidity Survey. [PDF]

, 2011
Evidence for an effect of work stressors on common mental disorders (CMD) has increased over the past decade. However, studies have not considered whether the effects of work stressors on CMD remain after taking co-occurring non-work stressors into ...
Jenkins, R., C. Pike, McManus, S., Brugha, T, Bebbington, Paul, Bebbington, P., Weich, S., R. Jenkins, Pike, C, T. Brugha, S. Weich, J. Harris, Weich, S, Clark, C., McManus, Sally, Meltzer, H, Meltzer, H., C. Clark, Stansfeld, Stephen, S. Stansfeld, Brugha, T. S. (Traolach S.), Brugha, T., Meltzer, Howard, McManus, S, Harris, J., Jenkins, Rachel, S. McManus, Jenkins, R, Harris, J, Bebbington, P. E., Stansfeld, S, P. Bebbington, Clark, C, Pike, C., Bebbington, P, H. Meltzer, Stansfeld, S., Clarke, C., Weich, Scott   +38 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Engaging with the Environment in the Industrialized Russian North

Suomen Antropologi, 2011
This article deals with the complexity of relations of urban dwellers with the natural environment. It explores a rich variety of practices in engaging with non-built environments developed by the population of mining cities in the Murmansk region ...
Alla Bolotova
doaj   +1 more source

Systematic review on the association between employee worktime control and work-non-work balance, health and well-being, and job-related outcomes [PDF]

, 2012
Contains fulltext : 102930.pdf (Publisher’s version ) (Open Access)Objectives The aim of this review was to assess systematically the empirical evidence for associations between employee worktime control (WTC) and work non-work balance,
Nijp, H.H., Tucker, Philip,, Beckers, Debby G. J., Nijp, Hylco H., Tucker, P.T., Geurts, Sabine A. E., Geurts, S.A.E., Beckers, D.G.J., Philip Tucker, Kompier, M.A.J., Kompier, Michiel A. J.   +10 more
core   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Work environment adversity and non-communicable Disease risk among drivers working for application-based-cab-aggregators in an Indian metropolis

BMC Public Health
Background Bengaluru, a metropolis in Southern India, is one of the largest markets for cab aggregator companies. Drivers working for these companies play a vital role in urban transportation but unlike other drivers, their work pattern is stressful ...
Gautham Melur Sukumar, Mohana Balan Parivallal, Shalin Lily Giboy, Aditi Narendra Thakkar   +3 more
doaj   +1 more source

Human impacts on the physical environment

, 2001
Human activities affect the operation of physical environment processes, and the results rebound on the human world. The human factor is an important consideration in assessing climate, landform, and ecosystem changes.
Single, M.
core  

Eating and shift work – effects on habits, metabolism and performance

, 2010
Compared to individuals who work during the day, shift workers are at higher risk of a range of metabolic disorders and diseases (eg, obesity, cardiovascular disease, peptic ulcers, gastrointestinal problems, failure to control blood sugar levels, and ...
Löwden, Arne,, Holmbäck, Ulf C.,, Moreno, Claudia Roberta,, Lennernäs, Maria,, Tucker, Philip T.,, Wiklund, Maria Lennernäs,, Moreno, C.R.C.,, Ulf Holmbäck, Philip Tucker, Arne Lowden, Claudia Moreno, Maria Lennernäs   +11 more
core   +1 more source