Results 111 to 120 of about 12,220,401 (374)

Effect of long non-coding RNA DUXAP8 on proliferation, cycle and apoptosis of ovarian cancer cells by regulating miR-4677-3p

, 2021
CHEN Cen, Dan Su, LI Ningwei, Qin Jiang, WANG Yazhou   +4 more
openalex   +2 more sources

Nuclear weapons and European interests : Discussions in the Assembly of the Western European Union, 1955–1975 [PDF]

, 2011
In the 1950s and 1960s the Defence Committee of the Western European Union (WEU) Assembly submitted a series of conspicuous reports on nuclear control issues, culminating in a plea for an Atlantic nuclear force.
Megens, C.M,
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Long non-coding RNA UCA1 modulates cell proliferation and apoptosis by regulating miR-296-3p/Myc axis in acute myeloid leukemia [PDF]

, 2020
Jiajia Li, Meng Wang, Xiaofeng Chen
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Non‐proliferation [PDF]

Strategic Survey, 1980
openaire   +2 more sources

GIS based Integration and Analysis of multiple source Information for Non-Proliferation Studies [PDF]

, 2010
In recent years the volume and variety of information that needs to be analysed in the context of non-proliferation have been increasing continuously Therefore, an integrated, all-source information analysis is paramount for an efficient and effective ...
GONCALVES Joao, GUTJAHR Karl-Heinz, LISTNER C., LOREAUX P., MARPU P., NIEMEYER Irmgard, PATRONO A., USSORIO A., WOLFART Erik   +8 more
core  

Study of wavelength-shifting chemicals for use in large-scale water Cherenkov detectors

, 2011
Cherenkov detectors employ various methods to maximize light collection at the photomultiplier tubes (PMTs). These generally involve the use of highly reflective materials lining the interior of the detector, reflective materials around the PMTs, or ...
A. Bernstein, Abdel-Mottaleb, Allison, Dai, Dazeley, J. Dunmore, J. Felde, M. Sweany, M. Tripathi, R. Svoboda, S. Dazeley, Snavely, Sweany   +12 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source