Results 111 to 120 of about 12,076,128 (300)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Towards a south american theory of nuclear development: Nuclear autonomy and regional security
Cadernos Prolam/USPThis article aims to discuss the development of nuclear technology in South America through theoretical lenses that more accurately reflect the observable experiences of the region.
João Marcos Ferreira Pacheco +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
cdiener/proliferation: proliferation v0.3.4
, 2016 <p>This is archived repository of version 0.3.4 of the proliferation pipeline. It includes instructions and additional files to reproduce the entire analysis.</p> <p>For usage instruction please see the README.md file.</p ...
Christian Diener +3 more
core +1 more source
Em nome da autonomia e do desenvolvimento
Meridiano 47, 2017 The objective is to examine the positions adopted by Brazil on nuclear non-proliferation, disarmament and peaceful uses of nuclear energy in the beginning of this century.
Diego Santos Vieira de Jesus
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Sustainable nuclear non-proliferation. Case-study: Iran
Intergenerational Justice ReviewSustainable nuclear non-proliferation is only possible in a world without nuclear weapons. As long as there are nuclear weapons, the odds are that nuclear proliferation will happen, despite the existence of a comprehensive nuclear non-proliferation ...
Tom Sauer
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Can donor coordination solve the aid proliferation problem ? [PDF]
The paper augments Holmstrom’s (1982) team production model in the context of aid effectiveness. The analysis shows how donor proliferation leads to inefficient supply of aid in the recipient country because of the free-riding problem faced by the donors.
Sawada, Yasuyuki, Rahman, Aminur
core