Results 31 to 40 of about 1,391,444 (333)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

open access: yesFEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera   +4 more
wiley   +1 more source

The Guterres Disarmament Agenda and the Challenge of Constructing a Global Regime for Weapons

open access: yesJournal for Peace and Nuclear Disarmament, 2020
On 24 May 2018, United Nations Secretary-General António Guterres launched his new “disarmament agenda” in an address at the University of Geneva.
Randy Rydell
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

open access: yesFEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Introduction: Reducing the Risk of Nuclear Weapons Use in Northeast Asia

open access: yesJournal for Peace and Nuclear Disarmament
This paper summarises the joint collaborative project between the Nautilus Institute, the Research Center for Nuclear Weapon Abolition, Nagasaki University (RECNA), the Asia Pacific Leadership Network for Nuclear Non-Proliferation and Disarmament (APLN ...
Shatabhisha Shetty
doaj   +1 more source

Bayesian inference of a non-local proliferation model

open access: yesRoyal Society Open Science, 2021
From a systems biology perspective, the majority of cancer models, although interesting and providing a qualitative explanation of some problems, have a major disadvantage in that they usually miss a genuine connection with experimental data. Having this
Zuzanna Szymańska   +3 more
doaj   +1 more source

Shared Responsibilities for Nuclear Disarmament: A Global Debate [PDF]

open access: yes, 2010
Presents Sagan's 2009 paper calling for rethinking the balance of responsibilities and the relationship between articles in the Nuclear Non-Proliferation Treaty with seven response papers by international scholars about how to pursue nuclear ...
Achilles Zaluar   +7 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

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