Results 41 to 50 of about 21,300,426 (351)
Introduction: Reducing the Risk of Nuclear Weapons Use in Northeast Asia
Journal for Peace and Nuclear DisarmamentThis paper summarises the joint collaborative project between the Nautilus Institute, the Research Center for Nuclear Weapon Abolition, Nagasaki University (RECNA), the Asia Pacific Leadership Network for Nuclear Non-Proliferation and Disarmament (APLN ...
Shatabhisha Shetty
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Molecular Cancer, 2020 N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is very limited. We designed this study to investigate the role of m6A in CRC.
X. Yang +9 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Bayesian inference of a non-local proliferation model
Royal Society Open Science, 2021 From a systems biology perspective, the majority of cancer models, although interesting and providing a qualitative explanation of some problems, have a major disadvantage in that they usually miss a genuine connection with experimental data. Having this
Zuzanna Szymańska +3 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
NATO's Role in Nuclear Non-Proliferation and Arms Control: A (Critical) History
, 2021 This paper looks at the interaction between the Atlantic Alliance and the main arms-control negotiations of the nuclear age. The first part is dedicated to the role the Alliance played in the arms-control and non-proliferation process that shaped the ...
Nuti, Leopoldo
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal for Peace and Nuclear DisarmamentThis article addresses challenges the International Atomic Energy Agency (IAEA) may face when conducting nuclear verification activities in former nuclear-armed States after the completion of their disarmament process.
Leonardo Bandarra +2 more
doaj +1 more source
Nuclear weapons: the state of play [PDF]
, 2013 The Crawford School of Public Policy’s Centre for Nuclear Non-Proliferation and Disarmament (CNND) this week launched in Geneva a major book-length report authoritatively documenting the unhappily diminishing global enthusiasm for nuclear disarmament ...
Ramesh Thakur, Gareth Evans
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