Results 41 to 50 of about 12,220,401 (374)

Introduction: Reducing the Risk of Nuclear Weapons Use in Northeast Asia

Journal for Peace and Nuclear Disarmament
This paper summarises the joint collaborative project between the Nautilus Institute, the Research Center for Nuclear Weapon Abolition, Nagasaki University (RECNA), the Asia Pacific Leadership Network for Nuclear Non-Proliferation and Disarmament (APLN ...
Shatabhisha Shetty
doaj   +1 more source

Bayesian inference of a non-local proliferation model

Royal Society Open Science, 2021
From a systems biology perspective, the majority of cancer models, although interesting and providing a qualitative explanation of some problems, have a major disadvantage in that they usually miss a genuine connection with experimental data. Having this
Zuzanna Szymańska, Jakub Skrzeczkowski, Błażej Miasojedow, Piotr Gwiazda   +3 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Long non‐coding RNA CCAT1 sponges miR‐490 to enhance cell proliferation and migration of non‐small cell lung cancer

Thoracic Cancer, 2021
Background Non‐small cell lung cancer (NSCLC) accounts for 85% of lung cancer which is the most frequently diagnosed malignancy in China. Colon cancer associated transcript 1 (CCAT1) acts as an oncogene in enhancing tumor progression.
Jingluan Wang, Nina Sun, Weizhong Han, Li Tong, Tao Xu, Guo Li   +5 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The IAEA and Irreversibility: Addressing Political, Institutional, and Technological Verification Challenges in Former Nuclear-Armed States

Journal for Peace and Nuclear Disarmament
This article addresses challenges the International Atomic Energy Agency (IAEA) may face when conducting nuclear verification activities in former nuclear-armed States after the completion of their disarmament process.
Leonardo Bandarra, Noah Mayhew, Malte Göttsche   +2 more
doaj   +1 more source

Export Control Regulations in the United Arab Emirates - Comparative Analysis with the United Kingdom [PDF]

, 2019
Governments across the world appreciate the need for checks on the transfer or exportation of commodities, information, software, and technology considered of strategic value.
Malkawi, Bashar H.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source