Results 21 to 30 of about 359,465 (284)

Oral diabetes medication monotherapy and short-term mortality in individuals with type 2 diabetes and coronary artery disease [PDF]

, 2018
Objective To determine whether sulfonylurea use, compared with non-sulfonylurea oral diabetes medication use, was associated with 2-year mortality in individuals with well-controlled diabetes and coronary artery disease (CAD). Research design and methods
Berkowitz, Seth A, Caplan, Liron, Grunwald, Gary K, Liu, Wenhui G, Maddox, Thomas M, Raghavan, Sridharan, Reusch, Jane E.B, Saxon, David R   +7 more
core   +3 more sources

Testing proportional hazards for specified covariates

Modern Stochastics: Theory and Applications, 2019
Tests for proportional hazards assumption concerning specified covariates or groups of covariates are proposed. The class of alternatives is wide: log-hazard rates under different values of covariates may cross, approach, go away.
Vilijandas Bagdonavičius, Rūta Levulienė   +1 more
doaj   +1 more source

Analysis of time to event outcomes in randomized controlled trials by generalized additive models. [PDF]

PLoS ONE, 2015
BACKGROUND:Randomized Controlled Trials almost invariably utilize the hazard ratio calculated with a Cox proportional hazard model as a treatment efficacy measure.
Christos Argyropoulos, Mark L Unruh
doaj   +1 more source

Are non-constant rates and non-proportional treatment effects accounted for in the design and analysis of randomised controlled trials? A review of current practice

BMC Medical Research Methodology, 2019
Background Most clinical trials with time-to-event primary outcomes are designed assuming constant event rates and proportional hazards over time. Non-constant event rates and non-proportional hazards are seen increasingly frequently in trials.
Kim Jachno, Stephane Heritier, Rory Wolfe   +2 more
doaj   +1 more source

Time and dose dependency of bone-sarcomas in patients injected with radium-224 [PDF]

, 1988
The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear ...
A. M. Kellerer, C. E. Land, C. W. Mays, CE Land, Committee on the biological effects of ionizing radiations, CW Mays, CW Mays, CW Mays, CW Mays, D Chmelevsky, D. Chmelevsky, H Spiess, H. Spiess, JS Spratt, RR Wick   +14 more
core   +1 more source

Weighted Cox Regression Using the R Package coxphw

Journal of Statistical Software, 2018
Cox's regression model for the analysis of survival data relies on the proportional hazards assumption. However, this assumption is often violated in practice and as a consequence the average relative risk may be under- or overestimated.
Daniela Dunkler, Meinhard Ploner, Michael Schemper, Georg Heinze   +3 more
doaj   +1 more source

Treating non-responders: pitfalls and implications for cancer immunotherapy trial design

Journal of Hematology & Oncology, 2020
Background Conventional trial design and analysis strategies fail to address the typical challenge of immune-oncology (IO) studies: only a limited percentage of treated patients respond to the experimental treatment.
Zhenzhen Xu, Yongsoek Park, Ke Liu, Bin Zhu   +3 more
doaj   +1 more source

A modified weighted log-rank test for confirmatory trials with a high proportion of treatment switching [PDF]

, 2020
In confirmatory cancer clinical trials, overall survival (OS) is normally a primary endpoint in the intention-to-treat (ITT) analysis under regulatory standards. After the tumor progresses, it is common that patients allocated to the control group switch
Bore, Alexander, Burman, Carl-Fredrik, Jiménez, José L., Niewczas, Julia   +3 more
core   +2 more sources

Which test for crossing survival curves? A user’s guideline

BMC Medical Research Methodology, 2022
Background The exchange of knowledge between statisticians developing new methodology and clinicians, reviewers or authors applying them is fundamental. This is specifically true for clinical trials with time-to-event endpoints.
Ina Dormuth, Tiantian Liu, Jin Xu, Menggang Yu, Markus Pauly, Marc Ditzhaus   +5 more
doaj   +1 more source

Partially linear censored quantile regression [PDF]

, 2009
Censored regression quantile (CRQ) methods provide a powerful and flexible approach to the analysis of censored survival data when standard linear models are felt to be appropriate.
B Honore, JL Powell, K Doksum, L Peng, L Tian, M Buchinsky, R Koenker, R Koenker, R Koenker, RJ Gray, S Portnoy, Stephen Portnoy, T Neocleous, Tereza Neocleous, V Chernozhukov, X He, X He, X He   +17 more
core   +1 more source