Results 81 to 90 of about 335,095 (291)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Gene selection in microarray survival studies under possibly non-proportional hazards [PDF]

Bioinformatics, 2010
AbstractMotivation: Univariate Cox regression (COX) is often used to select genes possibly linked to survival. With non-proportional hazards (NPH), COX could lead to under- or over-estimation of effects.The effect size measure c=P(T1<T0), i.e.
Daniela Dunkler, Georg Heinze, Michael Schemper   +2 more
openaire   +2 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Mortality in people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 6,724 patients with 2 years follow-up

Clinical Epidemiology, 2018
Simona Hapca,1 Bruce Guthrie,1 Vera Cvoro,2 Feifei Bu,3 Alasdair C Rutherford,3 Emma Reynish,3 Peter T Donnan1 1Population Health and Genomics, School of Medicine, University of Dundee, Dundee DD2 4BF, UK; 2NHS Fife, Kirkcaldy, Fife KY2 5AH, UK ...
Hapca S, Guthrie B, Cvoro V, Bu F, Rutherford AC, Reynish E, Donnan PT   +6 more
doaj  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The non-linear link between non-high-density lipoprotein to high-density lipoprotein ratio and the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study

Frontiers in Endocrinology
ObjectiveThis study aims to assess the association between the non-HDL-c/HDL-c ratio and stroke risk among middle-aged and older adults participating in the China Health and Retirement Longitudinal Study (CHARLS).MethodsThis study conducted a prospective
Lanbo Wang, Yong Han, Yong Han, Changchun Cao, Haofei Hu, Haofei Hu, Han Li   +6 more
doaj   +1 more source

Effects of Smoking on Menopausal Age: Results From the Korea National Health and Nutrition Examination Survey, 2007 to 2012 [PDF]

Journal of Preventive Medicine and Public Health, 2015
Objectives: Decreased fertility and impaired health owing to early menopause are significant health issues. Smoking is a modifiable health-related behavior that influences menopausal age.
Hee Jung Yang, Pae Sun Suh, Soo Jeong Kim, Soon Young Lee   +3 more
doaj   +1 more source

On the use of Fractional Polynomials in Dynamic Cox Models [PDF]

, 2000
Despite a sophisticated research on modelling of survival data in the last years, the most popular model used in practice is still the proportional hazards regression model proposed by Cox (1972).
Berger, Ursula, Gerein, Pia, Schäfer, Juliane, Ulm, Kurt   +3 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Increased Risk of Pulmonary Tuberculosis in Patients with Depression: A Cohort Study in Taiwan

Frontiers in Psychiatry, 2017
Background/objectiveTuberculosis (TB) and depression were major public health issues worldwide and the mutual causative relationships between them were not exhaustive. This study was performed to explore the association between depression, comorbidities,
Kao-Chi Cheng, Kao-Chi Cheng, Kuan-Fu Liao, Kuan-Fu Liao, Kuan-Fu Liao, Cheng-Li Lin, Cheng-Li Lin, Shih-Wei Lai, Shih-Wei Lai   +8 more
doaj   +1 more source