Results 81 to 90 of about 359,465 (284)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Association of Acidemia With Short-Term Mortality of Acute Myocardial Infarction: A Retrospective Study Base on MIMIC-III Database

Clinical and Applied Thrombosis/Hemostasis, 2020
Acute myocardial infarction (AMI) is a leading cause of death and not a few of these patients are combined with acidemia. This study aimed to detect the association of acidemia with short-term mortality of AMI patients.
Tang Zhang, Yao-Zong Guan, Hao Liu PhD
doaj   +1 more source

Modeling multilevel sleep transitional data via Poisson log-linear multilevel models [PDF]

, 2009
This paper proposes Poisson log-linear multilevel models to investigate population variability in sleep state transition rates. We specifically propose a Bayesian Poisson regression model that is more flexible, scalable to larger studies, and easily ...
Brian S. Caffo, Bruce J. Swihart, Bruce J. Swihart, Bruce J. Swihart, Naresh M. Punjabi   +4 more
core   +2 more sources

Modelling non-proportional hazard for survival data with different systematic components

Environmental and Ecological Statistics, 2020
We propose a new extended regression model based on the logarithm of the generalized odd log-logistic Weibull distribution with four systematic components for the analysis of survival data. This regression model can be very useful and could give more realistic fits than other special regression models.
Fábio Prataviera, Selene M. C. Loibel, Kathleen F. Grego, Edwin M. M. Ortega, Gauss M. Cordeiro   +4 more
openaire   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Application of Fractional Polynomial Model for Determining Prognostic Factors Associated with Survival of Patients with Gastric Cancer

مجله اپیدمیولوژی ایران, 2013
Background & Objectives: Cox regression model is one of the statistical methods in survival analysis. The use of smoothing techniques in Cox model makes the more accurate estimates for the parameters.
H Noorkojuri, E Hajizadeh, AR Baghestani, MA Pourhoseingholi   +3 more
doaj  

A transformer model for cause-specific hazard prediction

BMC Bioinformatics
Backgroud Modelling discrete-time cause-specific hazards in the presence of competing events and non-proportional hazards is a challenging task in many domains.
Matthieu Oliver, Nicolas Allou, Marjolaine Devineau, Jèrôme Allyn, Cyril Ferdynus   +4 more
doaj   +1 more source

Bayesian Analysis of Hazard Regression Models under Order Restrictions on Covariate Effects and Ageing [PDF]

, 2007
We propose Bayesian inference in hazard regression models where the baseline hazard is unknown, covariate effects are possibly age-varying (non-proportional), and there is multiplicative frailty with arbitrary distribution.
Bhattacharjee, Arnab, Bhattacharjee, Madhuchhanda   +1 more
core   +4 more sources

Methods for non-proportional hazards in clinical trials: A systematic review

Statistical Methods in Medical Research
For the analysis of time-to-event data, frequently used methods such as the log-rank test or the Cox proportional hazards model are based on the proportional hazards assumption, which is often debatable. Although a wide range of parametric and non-parametric methods for non-proportional hazards has been proposed, there is no consensus on the best ...
Maximilian Bardo, Cynthia Huber, Norbert Benda, Jonas Brugger, Tobias Fellinger, Vaidotas Galaune, Judith Heinz, Harald Heinzl, Andrew C Hooker, Florian Klinglmüller, Franz König, Tim Mathes, Martina Mittlböck, Martin Posch, Robin Ristl, Tim Friede   +15 more
openaire   +4 more sources