Results 91 to 100 of about 10,758,008 (293)

Sarcopenia index based on serum creatinine and cystatin C is associated with the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study

BMC Neurology
Objective The sarcopenia index (SI), calculated as the serum creatinine divided by the serum cystatin C, multiplied by 100, is recommended for predicting sarcopenia. However, limited evidence exists regarding its association with incident stroke. The aim
Haofei Hu, Aiting Li, Wenhao Zhang, Jihua Hou, Dinglin Liu, Zhijin Chen, Caiyan Zheng, Lele Qin, Yong Han, Lixia Xu, Zhiming Ye   +10 more
doaj   +1 more source

Efficient and Debiased Learning of Average Hazard Under Non-Proportional Hazards

Main paper: 24 pages and 2 figures; Reference and Supplement: 22 pages and 8 ...
Meng, Xiang, Tian, Lu, Kehl, Kenneth, Uno, Hajime   +3 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A transformer model for cause-specific hazard prediction

BMC Bioinformatics
Backgroud Modelling discrete-time cause-specific hazards in the presence of competing events and non-proportional hazards is a challenging task in many domains.
Matthieu Oliver, Nicolas Allou, Marjolaine Devineau, Jèrôme Allyn, Cyril Ferdynus   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent [PDF]

We introduce a pathwise algorithm for the Cox proportional hazards model, regularized by convex combinations of l_1 and l_2 penalties (elastic net). Our algorithm fits via cyclical coordinate descent, and employs warm starts to find a solution along a ...
Trevor Hastie, Noah Simon, Jerome H. Friedman, Rob Tibshirani   +3 more
core  

Association of Acidemia With Short-Term Mortality of Acute Myocardial Infarction: A Retrospective Study Base on MIMIC-III Database

Clinical and Applied Thrombosis/Hemostasis, 2020
Acute myocardial infarction (AMI) is a leading cause of death and not a few of these patients are combined with acidemia. This study aimed to detect the association of acidemia with short-term mortality of AMI patients.
Tang Zhang, Yao-Zong Guan, Hao Liu PhD
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Lagged Duration Dependence in Mixed Proportional Hazard Models [PDF]

We study the non-parametric identification of a mixed proportional hazard model with lagged duration dependence when data provide multiple outcomes per individual or stratum.
Matteo PICCHIO
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source