Results 81 to 90 of about 10,758,008 (293)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cox proportional hazards regression model.
, 2014 Cox proportional hazards regression model (n = 309 episodes in 1117 patients).Cox proportional hazards regression model.
Juan Wang (115708) +10 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
A pan-cancer multi-omic SuperLearner for regulated cell death survival topologies
Frontiers in Artificial IntelligenceIntroductionRegulated cell death (RCD) pathways influence tumor progression and immune modulation. We previously constructed a signature database mapping 25 RCD forms across seven multi-omic layers and 33 tumor types (CancerRCDShiny).
Emanuell Rodrigues de Souza +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The proportional representation review.
, 1893 Continued as a department of: Direct legislation record and the proportional representation review."A quarterly magazine, devoted to the reformation of the method of electing representatives."Title from cover.Mode of access: Internet.Revived and absorbed
American Proportional Representation League.
core
NON-PROPORTIONAL HAZARDS WITH APPLICATION TO KIDNEY TRANSPLANT DATA
Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 1999 The Cox proportional hazards (PH) model is the popular methodfor modelling censored survival data.Cox PH model is the proportionality of hazards in which the hazard ratiois linear in the covariates. However this assumption may not hold in somesurvival studies.
openaire +3 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
مجله اپیدمیولوژی ایران, 2013 Background & Objectives: Cox regression model is one of the statistical methods in survival analysis. The use of smoothing techniques in Cox model makes the more accurate estimates for the parameters.
H Noorkojuri +3 more
doaj