Results 1 to 10 of about 377,719 (123)

Effects of Postoperative Complications on Overall Survival Following Esophagectomy: A Meta-Analysis Using the Restricted Mean Survival Time Analysis. [PDF]

Thorac Cancer
This study aims to conduct a comprehensive meta‐analysis of the effects of postoperative complications (PCs) on survival following esophagectomy using the restricted mean survival time (RMST) analysis.
Yang Y, Han C, Xing X, Qin Z, Wang Q, Lan L, Zhu H.   +6 more
europepmc   +4 more sources

Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportional [PDF]

BMC Medical Research Methodology
Background Although the Cox time-varying coefficient (TVC) model has been developed to address non-proportional hazard (PH), its use remains underexplored.
Tianyuan Gu, Zhaojin Chen, Yu Yang Soon, Joseph Wee, Bee-Choo Tai   +4 more
doaj   +3 more sources

Re-evaluating Treatments for Advanced Urothelial Carcinoma Using Restricted Mean Survival Time: A Systematic Review and Network Meta-analysis [PDF]

European Urology Open Science
Background and objective: The proportional hazards (PH) assumption may not hold for immune checkpoint inhibitor (ICI) trials because of delayed treatment effects. We assessed PH validity in trials of first-line treatment in advanced urothelial carcinoma (
Shugo Yajima, Wei Chen, Kohei Hirose, Akihiro Hirakawa, Kenji Tanabe, Motohiro Fujiwara, Hiroshi Fukushima, Hajime Tanaka, Hitoshi Masuda, Yasuhisa Fujii, Soichiro Yoshida   +10 more
doaj   +3 more sources

Optimal two-stage designs based on restricted mean survival time for a single-arm study [PDF]

Contemporary Clinical Trials Communications, 2021
Restricted mean survival time is an alternative measure of treatment effect to hazard ratio in clinical trials with time-to-event outcome. The current methods have been focused on one-stage designs.
Guogen Shan
doaj   +4 more sources

Restricted Mean Survival Time—Can It Be a New Tool in Assessing the Survival of Non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors? [PDF]

Diagnostics, 2023
Background: Lung cancer (LC) is the first and most lethal cancer in the world; identifying new methods to treat it, such as immune checkpoint inhibitors (ICIs), is needed.
Cristina-Florina Pîrlog, Raluca Costache, Andreea Ioana Paroșanu, Cristina Orlov Slavu, Mihaela Olaru, Ana Maria Popa, Cristian Iaciu, Irina Niță, Pompilia Moțatu, Horia Teodor Cotan, Alexandru Vlad Oprița, Daniel Costache, Loredana Sabina Cornelia Manolescu, Cornelia Nițipir   +13 more
doaj   +3 more sources

Estimation of combined treatment effects by restricted mean survival time [PDF]

Trials
Background Restricted mean survival time (RMST) endpoints are becoming commonly used as trialists look to analyse time-to-event outcomes without the restrictions of the proportional hazards assumption. An additional benefit of RMST endpoints which has so
Emily Alger, David S. Robertson, Abigail J. Burdon   +2 more
doaj   +2 more sources

Causal effect estimation on restricted mean survival time under case-cohort design via propensity score stratification. [PDF]

Lifetime Data Anal
In large observational studies with survival outcome and low event rates, the case-cohort design is commonly used to reduce the cost associated with covariate measurement.
Lu WE, Ni A.
europepmc   +2 more sources

On Sample Size Determination for Augmented Tests Based on Restricted Mean Survival Time in Randomized Clinical Trials. [PDF]

Biom J
Restricted mean survival time (RMST) is gaining attention as a measure to quantify the treatment effect on survival outcomes in randomized clinical trials. Several methods to determine sample size based on the RMST‐based tests have been proposed. However,
Hattori S, Uno H.
europepmc   +2 more sources

Analyzing differences between restricted mean survival time curves using pseudo-values [PDF]

BMC Medical Research Methodology, 2022
Hazard ratios are ubiquitously used in time to event analysis to quantify treatment effects. Although hazard ratios are invaluable for hypothesis testing, other measures of association, both relative and absolute, may be used to fully elucidate study ...
Federico Ambrogi, Simona Iacobelli, Per Kragh Andersen   +2 more
doaj   +2 more sources

Roles of Restricted Mean Survival Time and Restricted Mean Time Lost in Evaluating Immune Checkpoint Inhibitor Efficacy for Extensive-Stage Small Cell Lung Cancer. [PDF]

Cancer Res Commun
Chemo-immunotherapy is the current standard of care for extensive-stage small cell lung cancer (ES-SCLC), but interpreting hazard ratios (HR) from Cox models can be challenging when immune checkpoint inhibitors (ICI) produce early crossing or delayed ...
Durer S, Fu P, Chen Z, Dowlati A.
europepmc   +2 more sources