Results 131 to 140 of about 4,698,088 (284)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Frontiers in Sports and Active LivingBackgroundChronic obstructive pulmonary disease (COPD) is a leading cause of chronic morbidity and mortality worldwide. Despite its significant public health burden, few studies have reported on the association of physical activity with incident COPD ...
Hao Wang +17 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Taking "Don't Knows" as Valid Responses: A Complete Random Imputation of Missing Data [PDF]
Incomplete data is a common problem of survey research. Recent work on multiple imputation techniques has increased analysts' awareness of the biasing effects of missing data and has also provided a convenient solution.
Martin Kroh
core
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Memorialising Trump's pandemic (non-)response
The Lancet Infectious Diseases, 2021 openaire +2 more sources
Bias Corrected Estimates of GED Returns [PDF]
Using three sources of data, this paper examines the direct economic return to GED certification for both native and immigrant high school dropouts. One data source %u2013 the CPS %u2013 is plagued by non-response and allocation bias from the hot-deck ...
James J. Heckman, Paul LaFontaine
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