Results 151 to 160 of about 4,740,266 (266)

Defining and Predicting HIV Immunological Non-Response: A Multi-Definition Analysis from an Indonesian Cohort. [PDF]

Viruses
Rachman BE, Supranoto YTN, Iskandar SI, Asmarawati TP, Khairunisa SQ, Arfijanto MV, Hadi U, Miftahussurur M, Nasronudin N, Kameoka M, Rahayu RP, Hidayati AN.   +11 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Recruitment Strategies, Response Rates, and Non-Response Patterns in a Nationwide Registry-Based PRO Survey of Cancer Survivors and the General Population: The SURV-ICE Cohort. [PDF]

Cancers (Basel)
Sigurðardóttir K, Friðriksdóttir N, Kristinsdóttir NM, Kristjánsdóttir L, Skúlason HG, Haraldsdóttir Á, Alfonsdóttir SÁ, Jóhannesdóttir AKB, Birgisson H, Tryggvadóttir H, Birgisdóttir F, Valdimarsdóttir H, Aspelund T, van de Poll-Franse L, Gunnarsdóttir S.   +14 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Negative health outcomes of non-response to the Kihon checklist in community-dwelling older people: a 19-month prospective cohort study. [PDF]

BMC Geriatr
Kazawa K, Moriyama M, Sato K, Ishii S.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

<i>ABCC</i> Gene Variants and Their Effects on Non-Response and Relapse in Pediatric Patients with Central Nervous System Tumors: A Cohort Study. [PDF]

Curr Issues Mol Biol
Torres-Espíndola LM, Pérez-De Marcos JC, Castillejos-López MJ, Aquino-Gálvez A, Velasco-Hidalgo L, Cárdenas-Cardós R, De Uña-Flores A, Zapata-Tarrés M, Higuera-Iglesias A.   +8 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Efficacy of Biologics in Patients with Ulcerative Colitis Exhibiting Non-Response or Insufficient Response to Cytapheresis. [PDF]

J Clin Med
Iizuka M, Etou T, Yorozu H, Kato B, Edagawa T, Sagara S, Matsushita HO, Yoshikawa K.   +7 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source