Results 131 to 140 of about 19,922,741 (302)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Non-linear morphodynamic response of deltas to extreme events

open access: yes
Deltas, the interface between riverine and coastal systems, host ∼500 million people and function as crucial ecological nexuses. The magnitude and frequency of extreme floods are projected to intensify as climate changes, yet the potential impacts on ...
Octria Prasojo (23967183)   +2 more
core   +3 more sources

Effects of Survey Design Features on Response Rates: A Meta-Analytical Approach Using the Example of Crime Surveys

open access: yesSurvey Research Methods
When conducting a survey, many choices regarding survey design features have to be made. These choices affect the response rate of a survey. This paper analyzes the individual effects of these survey design features on the response rate.
Jonas Klingwort, Vera Toepoel
doaj  

Re-engaging with Survey Non-respondents: The BHPS, SOEP and HILDA Survey Experience [PDF]

open access: yes
Previous research into the correlates and determinants of non-response in longitudinal surveys has focused exclusively on why it is that respondents at one survey wave choose not to participate at future waves. This is very understandable if non-response
Nicole Watson, Mark Wooden
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Inflammatory and Immune Pathways Driving Tumor Necrosis Factor Inhibitor Resistance in Ulcerative Colitis

open access: yesJournal of Inflammation Research
Morgan Fairweather,1 Ilaria Faggiani,2,3 Christopher Ma31Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; 2Department of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan ...
Fairweather M, Faggiani I, Ma C
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Exclusion of non-responses [PDF]

open access: yesAmerican Journal of Hypertension, 1996
M MYERS   +7 more
openaire   +1 more source

Representative Sampling and Survey Non‐Response

open access: yes, 2011
This chapter aims to determine whether opinion polls can accurately measure the political preferences of the US population, defining survey non-response and differentiating between unit non-response and item non-response where information is usually ...
Adam J. Berinsky
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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