Results 161 to 170 of about 4,740,266 (266)

Non-Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis. [PDF]

Aliment Pharmacol Ther
Abbas N, Smith R, Lytvyak E, Scaravaglio M, Halliday N, Almahroos A, Eden N, Lloyd-Madden D, Sharma S, Ferguson J, Dyson JK, Thorburn D, Jones D, Montano-Loza AJ, Carbone M, Invernizzi P, Mells G, Culver EL, Trivedi PJ.   +18 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events. [PDF]

Commun Med (Lond)
van Eijs MJM, van der Wal MM, Klotškova HB, Dautzenberg NMM, Schuiveling M, Verheijden RJ, van Schaik FDM, Oldenburg B, Nierkens S, UNICIT Consortium, Suijkerbuijk KPM, van Wijk F.   +11 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Author Correction: Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events. [PDF]

Commun Med (Lond)
van Eijs MJM, van der Wal MM, Klotškova HB, Dautzenberg NMM, Schuiveling M, Verheijden RJ, van Schaik FDM, Oldenburg B, Nierkens S, UNICIT Consortium, Suijkerbuijk KPM, van Wijk F.   +11 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Secondary Non-Response to Biologic Treatment in Patients with Severe Asthma. [PDF]

J Asthma Allergy
Mobayed H, Al-Nesf M, Ibrahim T, Aqel S, Al-Ahmad M, Bousquet J.   +5 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Early Non-Response to Neoadjuvant Chemotherapy Will Increase the Recurrence of Cervical Cancer: A Systematic Review. [PDF]

Biomedicines
Huang S, Yang R, Yang L, Kong S, Huang K.   +4 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source