Results 101 to 110 of about 1,075,360 (295)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Impact of adjuvant immunotherapy on prognosis in esophageal squamous cell carcinoma patients following neoadjuvant immunochemotherapy

Frontiers in Oncology
IntroductionThe CheckMate-577 trial confirmed that adjuvant nivolumab significantly prolonged disease-free survival (DFS) in patients with esophageal cancer who had residual disease after neoadjuvant chemoradiotherapy (nCRT).
Jiayi Geng, Jiayi Geng, Jiayi Geng, Jiayi Geng, Jiayi Geng, Bengang Hui, Teng Mu, Ni Ping , Runmin Jiang, Xiuyuan Chen, Xiuyuan Chen, Xiuyuan Chen, Xiuyuan Chen, Xiuyuan Chen, Heng Zhao, Heng Zhao, Heng Zhao, Heng Zhao, Heng Zhao, Dan zeng duo ji , Xizhao Sui, Xizhao Sui, Xizhao Sui, Xizhao Sui, Xizhao Sui, Yun Li, Yun Li, Yun Li, Yun Li, Yun Li, Xun Wang, Xun Wang, Xun Wang, Xun Wang, Xun Wang, Jie Lei   +35 more
doaj   +1 more source

Systemic treatment of non-small cell lung cancer brain metastases

Contemporary Oncology, 2016
In the systemic treatment of brain metastases from non-small cell lung cancer (BMF-NSCLC) chemo- and targeted therapy are used. Response rates after platinum-based chemotherapy, range from 23% to 45%.
Ida Cedrych, Maksymilian A. Kruczała, Tomasz Walasek, Jerzy Jakubowicz, Paweł Blecharz, Marian Reinfuss   +5 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Consensus on Application of Third-generation EGFR-TKI in EGFR Mutated NSCLC 
(2022 Version)

Chinese Journal of Lung Cancer, 2022
Chinese Society of Clinical Oncology (CSCO) Non-small Cell Lung Cancer Committee, Anti-cancer Drug Safety Management Committee (ASMC)   +1 more
doaj   +1 more source

LncRNA MIR503HG Inhibits Non-Small Cell Lung Cancer Cell Proliferation by Inducing Cell Cycle Arrest Through the Downregulation of Cyclin D1

Cancer Management and Research, 2020
Shufen Xu,* Shengping Zhai,* Tiantian Du,* Zhan Li Respiratory Department, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai City, Shandong Province 264000, People’s Republic of China*These authors contributed equally to this ...
Xu S, Zhai S, Du T, Li Z
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

2nd ESMO Consensus Conference on Lung Cancer: non-small-cell lung cancer first-line/second and further lines of treatment in advanced disease [PDF]

, 2017
This manuscript provides recommendations for first-line / second and further lines of treatment in advanced disease in non-small cell lung cancer (NSCLC). These recommendations were developed during the 2nd ESMO Consensus Conference on Lung Cancer in May
Adjei, A., Adjei, Alex, Baas, P., Baas, Paul, Besse, B., Besse, Benjamin, Bubendorf, Lukas, Crinò, Lucio, De Leyn, Paul, De Ruysscher, Dirk, Dooms, Christophe, Douillard, Jean-Yves, Eberhardt, Wilfried, Edelman, Martin, Faivre-Finn, Corinne, Felip, E., Felip, Enriqueta, Kerr, Keith, Le Pechoux, Cecile, Lim, Eric, Marchetti, Antonio, Meldgaard, P., Meldgaard, Peter, Mok, Tony, Nicolson, M., Nicolson, Marianne, Novello, Silvia, O'Byrne, Ken, Paz-Ares, L., Paz-Ares, Luis, Peters, S., Peters, Solange, Reck, M., Reck, Martin, Rocco, Gaetano, Senan, Suresh, Smit, E. F., Smit, Egbert F., Stahel, R., Stahel, Rolf, Syrigos, K., Syrigos, Konstantinos, Van Schil, Paul, Vansteenkiste, Johan, Veronesi, Giulia, Weder, Walter, Westeel, Virginie   +46 more
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Radiomics for Response and Outcome Assessment for Non-Small Cell Lung Cancer. [PDF]

, 2018
Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung ...
Benedict, Stanley, He, Yaoyao, Qiu, Jianfeng, Rong, Yi, Shi, Liting, Valicenti, Richard, Yuan, Zilong   +6 more
core   +1 more source