Results 71 to 80 of about 710,958 (307)

Increased HAGLR expression promotes non–small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis

Tumor Biology, 2017
Lung cancers are broadly classified into small cell lung cancer and non–small cell lung cancer, with non–small cell lung cancer one of the leading causes of cancer-associated deaths worldwide.
Chunwei Lu, Jun Ma, Dingfang Cai
doaj   +1 more source

Maintenance therapies for non small cell lung cancer

Frontiers in Oncology, 2014
Treatment of lung cancer had evolved during the last decade with the introduction of new chemotherapeutic regimens and targeted therapies. However, the maximum benefit reached after first line therapy is limited by the cumulative toxicity of platinum ...
Normand eBlais, Elie eKassouf
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Update in non small- cell lung cancer staging

Journal of the Belgian Society of Radiology, 2013
Significant progress has been made with the introduction of the TNM-7 staging system for non-small cell lung cancer (NSCLC). Constituting the first major revision in 12 years, the seventh edition of NSCLC TNM (TNM-7) is based on the recommendations from ...
RA Salgado, A Snoeckx, M Spinhoven, B Op de Beeck, B Corthouts, PM Parizel   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Coexistence of EGFR T790M mutation and common activating mutations in pretreatment non-small cell lung cancer: A systematic review and meta-analysis

, 2017
Objective: Previous studies have indicated that EGFR exon 19 deletions in non-small cell lung cancer (NSCLC) are associated with better outcomes to tyrosine kinase inhibitors (TKIs) than the L858R mutation.
Chen, Li-Yang;Molina-Vila, Miguel A.;Ruan, Sheng-Yuan;Su, Kang-Yi;Liao, Wei-Yu;Yu, Kai-Lun;Ho, Chao-Chi;Shih, Jin-Yuan;Yu, Chong-Jen;Yang, James Chih-Hsin;Rosell, Rafael;Yang, Pan-Chyr, 楊志新;蘇剛毅;廖唯昱;余忠仁;何肇基;阮聖元;施金元   +1 more
core   +1 more source

Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas. [PDF]

, 2002
We have previously described a group of non-small cell lung carcinomas without morphological evidence of neo-angiogenesis. In these tumours neoplastic cells fill up the alveoli and the only vessels present appear to belong to the trapped alveolar septa ...
Nicholson, Andrew G., C Ratcliffe, N Singh, P Goldstraw, A G Nicholson, Trivella, M, A Cesario, Granone, Pierluigi, Passalidou, Elisabeth, E Passalidou, Leigh, Irene, Ratcliffe, C, Trivella, Maria-Heleni, Leigh, I, Granone, P, Passalidou, E, Cesario, A, Harris, AL, I Leigh, Nicholson, AG, Pezzella, F, Tetlow, Michelle, Goldstraw, P, Singh, N, J Hu, K C Gatter, Hu, J, Ratcliffe, Cathy, F Pezzella, Goldstraw, Peter, P Granone, A L Harris, Gatter, KC, Singh, Neeta, Gatter, Kevin C., Ferguson, M, Ferguson, Michael, M Trivella, M Ferguson, Tetlow, M, Gatter, Kevin, Pezzella, Francesco, Hu, Jiangting, Harris, Adrian L., M Tetlow, Cesario, Alfredo   +45 more
core   +1 more source

HBXIP suppression reduces cell proliferation and migration and its overexpression predicts poor prognosis in non-small-cell lung cancer

Tumor Biology, 2017
Emerging evidence has demonstrated that the high expression of HBXIP has been correlated with many cancers. With evaluation of the functional role of HBXIP in non-small-cell lung cancer, the primary aim of this study is to investigate the correlation ...
Yixuan Wang, Nan Li, Shuanlong Che, Tiefeng Jin, Junjie Piao, Shuangping Liu, Zhenhua Lin   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comparison of platinum and non-platinum based regimens in the treatment of small cell lung cancer

, 2023
Small cell lung cancer, and lung cancer in general, remains one of the most impactful public health issues in the modern age due to its high morbidity and mortality.
Benyarko, Ato
core