Results 71 to 80 of about 1,075,360 (295)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Maintenance therapies for non small cell lung cancer

Frontiers in Oncology, 2014
Treatment of lung cancer had evolved during the last decade with the introduction of new chemotherapeutic regimens and targeted therapies. However, the maximum benefit reached after first line therapy is limited by the cumulative toxicity of platinum ...
Normand eBlais, Elie eKassouf
doaj   +1 more source

2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up [PDF]

, 2017
This manuscript provides recommendations for the diagnosis, treatment and follow-up of early stage non-small cell lung cancer developed during the 2nd ESMO Consensus Conference on Lung Cancer in May ...
Adjei, Alex, Baas, Paul, Besse, Benjamin, Bubendorf, Lukas, Crinò, L., Crinò, Lucio, De Leyn, Paul, De Ruysscher, Dirk, Dooms, C., Dooms, Christophe, Douillard, J. Y., Douillard, Jean-Yves, Eberhardt, Wilfried, Edelman, Martin, Faivre-Finn, C., Faivre-Finn, Corinne, Felip, E., Felip, Enriqueta, Kerr, Keith, Le Pechoux, Cecile, Lim, E., Lim, Eric, Marchetti, Antonio, Meldgaard, Peter, Mok, Tony, Nicolson, Marianne, Novello, Silvia, O'Byrne, Ken, Paz-Ares, Luis, Peters, S., Peters, Solange, Reck, Martin, Rocco, G., Rocco, Gaetano, Senan, S., Senan, Suresh, Smit, Egbert F., Stahel, R., Stahel, Rolf, Syrigos, Konstantinos, Van Schil, P., Van Schil, Paul, Vansteenkiste, J., Vansteenkiste, Johan, Veronesi, G., Veronesi, Giulia, Weder, Walter, Westeel, Virginie   +47 more
core  

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]

, 2015
BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir, Lewis, Michael, Lu, Jie, Mortazavi, Fariborz, Pezeshkpour, Gholamhossein, Phan, Ryan, Tamanoi, Fuyuhiko, Trinidad, Kenny   +7 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Update in non small- cell lung cancer staging

Journal of the Belgian Society of Radiology, 2013
Significant progress has been made with the introduction of the TNM-7 staging system for non-small cell lung cancer (NSCLC). Constituting the first major revision in 12 years, the seventh edition of NSCLC TNM (TNM-7) is based on the recommendations from ...
RA Salgado, A Snoeckx, M Spinhoven, B Op de Beeck, B Corthouts, PM Parizel   +5 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Increased HAGLR expression promotes non–small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis

Tumor Biology, 2017
Lung cancers are broadly classified into small cell lung cancer and non–small cell lung cancer, with non–small cell lung cancer one of the leading causes of cancer-associated deaths worldwide.
Chunwei Lu, Jun Ma, Dingfang Cai
doaj   +1 more source

Gene expression-based classification of non-small cell lung carcinomas and survival prediction [PDF]

, 2010
Background: Current clinical therapy of non-small cell lung cancer depends on histo-pathological classification. This approach poorly predicts clinical outcome for individual patients.
Aerts, J.G.J.V. (Joachim), Bakker, M.A. (Michael) den, Den Hamer, B. (Bianca), Foekens, J.A. (John), Grosveld, F.G. (Frank), Hoogsteden, H.C. (Henk), Hou, J. (Jun), IJcken, W.F.J. (Wilfred) van, Leest, K.H. (Cor) van der, Philipsen, J.N.J. (Sjaak), Riegman, P.H.J. (Peter), Spek, P.J. (Peter) van der   +11 more
core  

Inhibition of human lung cancer cell proliferation and survival by wine [PDF]

, 2014
Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits.
Barron, Carly, Moore, Jesse, Pickering, Gary, Tsakiridis, Theodoros, Tsiani, Evangelia   +4 more
core   +3 more sources