Advanced Materials, EarlyView.A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte +21 more
wiley +1 more source
Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study
Human Vaccines & Immunotherapeutics, 2018 Background: Bacillus Calmette-Guérin (BCG) vaccination may have beneficial non-specific effects on child survival, the effects being stronger for children developing a scar. In a prospective cohort study, we examined determinants for not developing a BCG
Katarina M. Funch +6 more
doaj +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Advanced Materials Interfaces, EarlyView.PEG‐guided mitochondrial surface engineering supports structural stabilization and controlled presentation of cell‐penetrating peptides. CPP–PEG‐modified mitochondria exhibit enhanced cellular uptake and uptake‐associated respiratory modulation, providing a proof‐of‐concept framework for modular organelle engineering and future bioenergetic modulation ...
Masahiro Shiraishi +9 more
wiley +1 more source
Correction to: Sex-Differential and Non-specific Effects of Vaccines Over the Life Course. [PDF]
Curr Top Microbiol Immunol, 2023 St Clair LA +4 more
europepmc +1 more source
Sustainable Plant‐Based Water Repellent Coatings Using Hydrophobic Pine and Palm Pollen
Advanced Materials Interfaces, EarlyView.A novel formulation strategy for creating superhydrophobic coatings using plant‐derived waxes and chemically treated pine and palm pollen. By employing acid modification, the hydrophobicity of the pollen surface is enhanced, resulting in water contact angles exceeding 150°.
Brenda Resendiz‐Diaz +2 more
wiley +1 more source
Letter to the editor RE: Berendsen et al., 2016 'Non-specific Effects of Vaccines and Stunting: Timing May Be Essential'. [PDF]
EBioMedicine, 2021 Ould Setti M, Ould Setti M.
europepmc +1 more source
Microneedles Mediated Delivery of Nanodiamonds for Quantum Sensing of Free Radicals in Skin Tissue
Advanced Materials Technologies, EarlyView.Fluorescent nanodiamonds are nanoscale sensors capable of monitoring cellular stress responses. However, to function effectively, they must be delivered into cells or tissues. Here, we demonstrate their application in the skin by developing a dissolvable microneedle platform that dissolves after skin insertion, enabling the delivery of nanodiamonds ...
Siyu Fan +10 more
wiley +1 more source
Neonatal Immunization: Rationale, Current State, and Future Prospects
Frontiers in Immunology, 2018 Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal
Elizabeth Whittaker +4 more
doaj +1 more source
In response to the Letter to the Editor by Ould Setti and Ould Setti RE: 'Non-specific Effects of vaccines and stunting: Timing May Be Essential'. [PDF]
EBioMedicine, 2021 Berendsen MLT +3 more
europepmc +1 more source