Patients’ perceptions on non‐specific effects of acupuncture: Qualitative comparison between responders and non‐responders [PDF]
Integrative Medicine Research, 2022 Background: Non-specific effect of acupuncture constitutes part of the overall effect generated via clinical encounter beyond needle insertion and stimulation. It is unclear how responders and non-responders of acupuncture experience non-specific effects
Robin S.T. Ho +7 more
doaj +5 more sources
Non-Specific Effects of Bacillus Calmette-Guérin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [PDF]
Vaccines, 2023 Background: Vaccines induce antigen-specific immunity, which provides long-lived protection from the target pathogen. Trials from areas with high incidence rates for infectious diseases indicated that the tuberculosis vaccine Bacillus Calmette-Guérin ...
Gerhard Trunk +2 more
doaj +5 more sources
Non-specific effects of vaccinations in high-income settings: How to address the issue? [PDF]
Human Vaccines & Immunotherapeutics, 2018 “Non-specific effects” of vaccines go beyond the specific protective effects against the targeted diseases. They, if real, could theoretically be beneficial, neutral or negative. This article intends to answer the following questions: Do the non-specific
Alberto Donzelli +2 more
doaj +3 more sources
Immunogenicity of Bacillus Calmette-Guérin in pigs: potential as a translational model of non-specific effects of BCG [PDF]
Frontiers in Immunology, 2023 BackgroundClinical and immunological studies in humans show that the live attenuated Bacillus Calmette-Guérin (BCG) vaccine has beneficial non-specific effects, increasing resistance against diseases other than tuberculosis. The underlying mechanisms are
Kristoffer Jarlov Jensen +12 more
doaj +2 more sources
Specific and non-specific effects of Mycobacterium bovis BCG vaccination in dairy calves [PDF]
Frontiers in Veterinary Science, 2023 Bovine tuberculosis (bTB) is a chronic disease mainly caused by Mycobacterium bovis, a zoonotic pathogen with economic significance as it leads to reduced milk and meat production, and high costs for control measures.
Catalina Contreras +5 more
doaj +2 more sources
Sex-differential non-specific effects of adjuvanted and non-adjuvanted rabies vaccines versus placebo on all-cause mortality in dogs (NERVE-Dog study): a study protocol for a randomized controlled trial with a nested case–control study [PDF]
BMC Veterinary Research, 2022 Background It has been proposed that childhood vaccines in high-mortality populations may have substantial impacts on mortality rates that are not explained by the prevention of targeted diseases, nor conversely by typical expected adverse reactions to ...
Darryn L. Knobel +10 more
doaj +2 more sources
Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia [PDF]
Frontiers in Psychiatry, 2021 The idea that maladaptive memories may be rendered susceptible to interference after reactivation raises the possibility of reactivating and neutralizing clinically-relevant emotional memories.
James W. B. Elsey, Merel Kindt
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Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations [PDF]
Frontiers in Immunology, 2018 Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these ...
Deeva Uthayakumar +9 more
doaj +2 more sources
Commentary: Beneficial non-specific effects of measles vaccine: Fact or fiction? [PDF]
Human Vaccines & ImmunotherapeuticsA PLOS One review has claimed that randomized controlled trials (RCTs) show no beneficial nonspecific effects (NSEs) of measles vaccine (MV). Since this claim contradicts previous meta-analyses, we examined the contradictory views.
Peter Aaby +4 more
doaj +2 more sources
Non-specific Effects of Vaccines and Stunting: Timing May Be Essential [PDF]
EBioMedicine, 2016 Background: Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in ...
Mike L.T. Berendsen +3 more
doaj +2 more sources