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The Yin and Yang of the Non-Specific Effects of Vaccines [PDF]
EBioMedicine, 2017 The Non-Specific Effects (NSE) of vaccines refers to any other effect of a given vaccine, other than the intended effect of reducing disease from the specific vaccination.
Stephen Cose
doaj +7 more sources
Non-specific Effects of Vaccines and Stunting: Timing May Be Essential [PDF]
EBioMedicine, 2016 Background: Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in ...
Mike L.T. Berendsen +3 more
doaj +8 more sources
Sex-Differential and Non-specific Effects of Vaccines Over the Life Course. [PDF]
Curr Top Microbiol Immunol, 2023 Biological sex and age have profound effects on immune responses throughout the lifespan and impact vaccine acceptance, responses, and outcomes. Mounting evidence from epidemiological, clinical, and animal model studies show that males and females respond differentially to vaccination throughout the lifespan.
St Clair LA +4 more
europepmc +5 more sources
Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations [PDF]
Frontiers in Immunology, 2018 Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these ...
Deeva Uthayakumar +9 more
doaj +3 more sources
Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19 [PDF]
Human Vaccines & Immunotherapeutics, 2021 No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, is recognized by some endosomal and cytosolic receptors following cell entry, entailing innate and adaptive immunity stimulation, notably through interferon induction ...
Pouria Mosaddeghi +4 more
doaj +4 more sources
Australia, immunisation, GAVI, and the non‐specific effects of vaccines [PDF]
Australian and New Zealand Journal of Public Health, 2012 Frank Shann
doaj +4 more sources
The non-specific and sex-differential effects of vaccines [PDF]
Nature Reviews Immunology, 2020 The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the same pathogen. However, evidence accumulated over the past few decades increasingly suggests that vaccines can also ...
Aaby, Peter +6 more
openaire +4 more sources
iScience, 2023 Summary: We examined the possible non-specific effects of novel mRNA- and adenovirus-vector COVID-19 vaccines by reviewing the randomized control trials (RCTs) of mRNA and adenovirus-vector COVID-19 vaccines. We calculated mortality risk ratios (RRs) for
Christine S. Benn +4 more
doaj +2 more sources
Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines [PDF]
Drug Safety, 2023 The current framework for testing and regulating vaccines was established before the realization that vaccines, in addition to their effect against the vaccine-specific disease, may also have "non-specific effects" affecting the risk of unrelated diseases.
Christine Stabell Benn +15 more
openaire +8 more sources
Non-specific effects of veterinary vaccines: a systematic review
Vaccine, 2022 The benefits of vaccines have been centred on their specific effects on subsequent infections by target pathogens. Recent studies, however, have opened up new insights into additional effects of vaccines known as non-specific effects (NSEs) or heterologous effects of vaccines.
Arega, Sintayehu +3 more
openaire +4 more sources