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The non-specific and sex-differential effects of vaccines [PDF]
Nature Reviews Immunology, 2020 The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the same pathogen. However, evidence accumulated over the past few decades increasingly suggests that vaccines can also ...
Peter Aaby +2 more
exaly +6 more sources
Non-specific Effects of Vaccines and Stunting: Timing May Be Essential [PDF]
EBioMedicine, 2016 Background: Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in ...
Mike L.T. Berendsen +3 more
doaj +8 more sources
Non-specific effects of vaccines: Current evidence and potential implications
Seminars in Immunology, 2018 Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations
Valerie A C M Koeken +2 more
exaly +8 more sources
Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations [PDF]
Frontiers in Immunology, 2018 Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these ...
Deeva Uthayakumar +9 more
doaj +4 more sources
The Yin and Yang of the Non-Specific Effects of Vaccines [PDF]
EBioMedicine, 2017 Stephen Cose
doaj +6 more sources
Expert Review of Vaccines, 2017 Introduction: Vaccines have heterologous effects on the immune system, leading to altered susceptibility to a range of pathogens, and possibly allergy and autoimmunity. Effects are often sex-differential.
Katie L. Flanagan, Magdalena Plebanski
doaj +4 more sources
Developing the concept of beneficial non-specific effect of live vaccines with epidemiological studies [PDF]
Clinical Microbiology and Infection, 2019 Epidemiological and immunological studies are increasingly reporting non-specific effects (NSEs) of vaccines; i.e. vaccines may affect the risk and severity of non-targeted infections. We reviewed how epidemiological studies developed the concept of beneficial NSEs of live vaccines.This is a personal narrative of how we came to pursue the concept of ...
Peter Aaby, Christine Stabell Benn
exaly +6 more sources
Sex-Differential and Non-specific Effects of Vaccines Over the Life Course. [PDF]
Curr Top Microbiol Immunol, 2023 Biological sex and age have profound effects on immune responses throughout the lifespan and impact vaccine acceptance, responses, and outcomes. Mounting evidence from epidemiological, clinical, and animal model studies show that males and females respond differentially to vaccination throughout the lifespan.
St Clair LA +4 more
europepmc +4 more sources
Harnessing the non-specific immunogenic effects of available vaccines to combat COVID-19 [PDF]
Human Vaccines & Immunotherapeutics, 2021 No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, is recognized by some endosomal and cytosolic receptors following cell entry, entailing innate and adaptive immunity stimulation, notably through interferon induction ...
Pouria Mosaddeghi +4 more
doaj +3 more sources
Human Vaccines & Immunotherapeutics, 2020 Children who had received MMR as the most recent vaccine had a pooled 35% (95%CI: 12–53%) lower risk for hospitalization due to any infectious disease, compared to children who had received DTaP as the most recent vaccine (three studies, 1,919,192 ...
Andrea Xaver Sinzinger +4 more
doaj +2 more sources