Results 11 to 20 of about 204,881 (211)

Non-specific Effects of Vaccines and Stunting: Timing May Be Essential [PDF]

EBioMedicine, 2016
Background: Bacillus Calmette-Guérin (BCG) vaccination possesses effects on health beyond its target disease, the so called “non-specific effects”. We evaluate these effects, as well as the effect of timing of BCG and other vaccinations, on stunting in ...
Mike L.T. Berendsen, Jeroen Smits, Mihai G. Netea, André van der Ven   +3 more
doaj   +2 more sources

Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations [PDF]

Frontiers in Immunology, 2018
Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these ...
Deeva Uthayakumar, Deeva Uthayakumar, Deeva Uthayakumar, Simon Paris, Simon Paris, Simon Paris, Ludivine Chapat, Ludovic Freyburger, Hervé Poulet, Karelle De Luca   +9 more
doaj   +2 more sources

The origin of non-specific effects of vaccines and the role of randomised clinical trials [PDF]

Human Vaccines & Immunotherapeutics
Recent articles claim that randomized clinical trials (RCTs) have not documented non-specific effects of vaccines (NSE), i.e. broader immunomodulatory effects of vaccines. We reviewed the role of RCTs in the discovery of NSEs.
Christine S. Benn, Sebastian Nielsen, Frederik Schaltz-Buchholzer, Peter Aaby   +3 more
doaj   +2 more sources

The Yin and Yang of the Non-Specific Effects of Vaccines [PDF]

EBioMedicine, 2017
Stephen Cose
doaj   +2 more sources

Heterologous vaccine interventions: boosting immunity against future pandemics

Molecular Medicine, 2021
While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection from unrelated pathogens.
Daniela Marín-Hernández, Douglas F. Nixon, Nathaniel Hupert   +2 more
doaj   +1 more source

Prospects on Repurposing a Live Attenuated Vaccine for the Control of Unrelated Infections

Frontiers in Immunology, 2022
Live vaccines use attenuated microbes to acquire immunity against pathogens in a safe way. As live attenuated vaccines (LAVs) still maintain infectivity, the vaccination stimulates diverse immune responses by mimicking natural infection.
Sang-Uk Seo, Baik-Lin Seong, Baik-Lin Seong   +2 more
doaj   +1 more source

National Immunization Campaigns with Oral Polio Vaccine Reduce All-Cause Mortality: A Natural Experiment within Seven Randomized Trials

Frontiers in Public Health, 2018
BackgroundA recent WHO review concluded that live BCG and measles vaccine (MV) may have beneficial non-specific effects (NSEs) reducing mortality from non-targeted diseases. NSEs of oral polio vaccine (OPV) were not examined. If OPV vaccination campaigns
Andreas Andersen, Ane Baerent Fisker, Amabelia Rodrigues, Cesario Martins, Henrik Ravn, Henrik Ravn, Najaaraq Lund, Sofie Biering-Sørensen, Christine Stabell Benn, Christine Stabell Benn, Peter Aaby, Peter Aaby, Peter Aaby   +12 more
doaj   +1 more source

Non-specific effects of MMR vaccines on infectious disease related hospitalizations during the second year of life in high-income countries: a systematic review and meta-analysis

Human Vaccines & Immunotherapeutics, 2020
Children who had received MMR as the most recent vaccine had a pooled 35% (95%CI: 12–53%) lower risk for hospitalization due to any infectious disease, compared to children who had received DTaP as the most recent vaccine (three studies, 1,919,192 ...
Andrea Xaver Sinzinger, Rüdiger Von Kries, Anette Siedler, Ole Wichmann, Thomas Harder   +4 more
doaj   +1 more source

Measles Vaccination in Presence of Measles Antibody May Enhance Child Survival

Frontiers in Pediatrics, 2020
Background: In trials of early two-dose measles vaccination (MV), with the first dose being given before 9 months of age, vaccination in the presence of maternal antibody reduced mortality 2- to 3-fold compared with MV in the presence of no measles ...
Christine S. Benn, Christine S. Benn, Christine S. Benn, Cesário L. Martins, Andreas Andersen, Andreas Andersen, Ane B. Fisker, Ane B. Fisker, Ane B. Fisker, Hilton C. Whittle, Peter Aaby, Peter Aaby   +11 more
doaj   +1 more source

Non-specific effects of rabies vaccine on the incidence of common infectious disease episodes: study protocol for a randomized controlled trial

Trials, 2020
Background Vaccines may cause non-specific effects (NSEs) on morbidity and mortality through immune-mediated mechanisms that are not explained by the prevention of the targeted disease.
Darryn Knobel, Christianah Ibironke Odita, Anne Conan, Donna Barry, Marshalette Smith-Anthony, Juliet Battice, Shianne England, Bradford D. Gessner   +7 more
doaj   +1 more source