Results 11 to 20 of about 349,591 (291)

The non-specific and sex-differential effects of vaccines [PDF]

Nature Reviews Immunology, 2020
The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the same pathogen. However, evidence accumulated over the past few decades increasingly suggests that vaccines can also ...
Aaby, Peter, Benn, Christine Stabell, Flanagan, Katie L., Klein, Sabra L., Kollmann, Tobias R., Lynn, David J., Shann, Frank   +6 more
openaire   +6 more sources

Non-specific effects of vaccines: Current evidence and potential implications

Seminars in Immunology, 2018
Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations
de Bree, L.C.J., Koeken, V.A.C.M., Joosten, L.A.B., Joosten, L.A.B., Aaby, P., Benn, C.S., van Crevel, R., van Crevel, R., Netea, M.G., Netea, M.G.   +9 more
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Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infections

The Lancet Infectious Diseases, 2023
Live attenuated vaccines could have beneficial, non-specific effects of protecting against vaccine-unrelated infections, such as BCG protecting against respiratory infection. During the COVID-19 pandemic, testing of these effects against COVID-19 was of interest to the pandemic control programme.
Aaby, Peter, Netea, Mihai G, Benn, Christine S   +2 more
openaire   +5 more sources

Developing the concept of beneficial non-specific effect of live vaccines with epidemiological studies [PDF]

Clinical Microbiology and Infection, 2019
Epidemiological and immunological studies are increasingly reporting non-specific effects (NSEs) of vaccines; i.e. vaccines may affect the risk and severity of non-targeted infections. We reviewed how epidemiological studies developed the concept of beneficial NSEs of live vaccines.This is a personal narrative of how we came to pursue the concept of ...
Aaby, P., Benn, C. S.
openaire   +6 more sources

Sex-differential heterologous (non-specific) effects of vaccines: an emerging public health issue that needs to be understood and exploited

Expert Review of Vaccines, 2017
Introduction: Vaccines have heterologous effects on the immune system, leading to altered susceptibility to a range of pathogens, and possibly allergy and autoimmunity. Effects are often sex-differential.
Katie L. Flanagan, Magdalena Plebanski
doaj   +2 more sources

How to evaluate potential non-specific effects of vaccines: the quest for randomized trials or time for triangulation?

Expert Review of Vaccines, 2018
Introduction: Emerging evidence suggests that vaccines, in addition to their disease-specific effects, have important non-specific effects (NSEs), which contribute to their overall effect on mortality and morbidity.
Christine Stabell Benn, Ane Bærent Fisker, Andreas Rieckmann, Aksel Karl Georg Jensen, Peter Aaby   +4 more
doaj   +2 more sources

Health effects of utilising hospital contacts to provide measles vaccination to children 9–59 months—a randomised controlled trial in Guinea-Bissau

Trials, 2022
Background Measles vaccination coverage in Guinea-Bissau is low; fewer than 80% of children are currently measles vaccinated before 12 months of age. The low coverage hampers control of measles.
Ane B. Fisker, Justiniano S. D. Martins, Andreas M. Jensen, Cesario Martins, Peter Aaby, Sanne M. Thysen   +5 more
doaj   +1 more source

One vaccine to counter many diseases? Modeling the economics of oral polio vaccine against child mortality and COVID-19

Frontiers in Public Health, 2022
IntroductionRecent reviews summarize evidence that some vaccines have heterologous or non-specific effects (NSE), potentially offering protection against multiple pathogens.
Angela Y. Chang, Angela Y. Chang, Peter Aaby, Peter Aaby, Michael S. Avidan, Christine S. Benn, Christine S. Benn, Christine S. Benn, Stefano M. Bertozzi, Stefano M. Bertozzi, Stefano M. Bertozzi, Lawrence Blatt, Lawrence Blatt, Konstantin Chumakov, Konstantin Chumakov, Shabaana A. Khader, Shyam Kottilil, Shyam Kottilil, Madhav Nekkar, Mihai G. Netea, Mihai G. Netea, Mihai G. Netea, Annie Sparrow, Dean T. Jamison   +23 more
doaj   +1 more source

Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines [PDF]

Drug Safety, 2023
The current framework for testing and regulating vaccines was established before the realization that vaccines, in addition to their effect against the vaccine-specific disease, may also have "non-specific effects" affecting the risk of unrelated diseases.
Christine Stabell Benn, Nelly Amenyogbe, Anders Björkman, Jorge Domínguez-Andrés, Eleanor N. Fish, Katie L. Flanagan, Sabra L. Klein, Tobias R. Kollmann, Kirsten Ohm Kyvik, Mihai G. Netea, Naja Hulvej Rod, Frederik Schaltz-Buchholzer, Frank Shann, Liisa Selin, Sanne M. Thysen, Peter Aaby   +15 more
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Randomized clinical trials of COVID-19 vaccines: Do adenovirus-vector vaccines have beneficial non-specific effects?

iScience, 2023
Summary: We examined the possible non-specific effects of novel mRNA- and adenovirus-vector COVID-19 vaccines by reviewing the randomized control trials (RCTs) of mRNA and adenovirus-vector COVID-19 vaccines. We calculated mortality risk ratios (RRs) for
Christine S. Benn, Frederik Schaltz-Buchholzer, Sebastian Nielsen, Mihai G. Netea, Peter Aaby   +4 more
doaj   +1 more source