Results 11 to 20 of about 205,611 (276)

The non-specific effects of vaccines and other childhood interventions: the contribution of INDEPTH Health and Demographic Surveillance Systems. [PDF]

Int J Epidemiol, 2014
Most childhood interventions (vaccines, micronutrients) in low-income countries are justified by their assumed effect on child survival. However, usually the interventions have only been studied with respect to their disease/deficiency-specific effects ...
Sankoh O, Welaga P, Debpuur C, Zandoh C, Gyaase S, Poma MA, Mutua MK, Hanifi SM, Martins C, Nebie E, Kagoné M, Emina JB, Aaby P.   +12 more
europepmc   +2 more sources

Non-specific effects of vaccines: plausible and potentially important, but implications uncertain [PDF]

Archives of Disease in Childhood, 2017
Non-specific effects (NSE) or heterologous effects of vaccines are proposed to explain observations in some studies that certain vaccines have an impact beyond the direct protection against infection with the specific pathogen for which the vaccines were designed. The importance and implications of such effects remain controversial.
Andrew J Pollard, Adam Finn, Nigel Curtis   +2 more
openaire   +5 more sources

Non-specific effects of childhood vaccines [PDF]

BMJ, 2016
Evidence of any “off target” effects remains weak and vulnerable to ...
Chee-Fu Yung
openaire   +3 more sources

Non-specific effects of vaccines: Current evidence and potential implications

Seminars in Immunology, 2018
Besides protection against specific microorganisms, vaccines can induce heterologous or non-specific effects (NSE). Epidemiological data suggest that vaccination with live-attenuated vaccines such as Bacillus Calmette-Guérin (BCG), measles vaccine, and oral polio vaccine results in increased overall childhood survival, and several of these observations
de Bree, L.C.J., Koeken, V.A.C.M., Joosten, L.A.B., Joosten, L.A.B., Aaby, P., Benn, C.S., van Crevel, R., van Crevel, R., Netea, M.G., Netea, M.G.   +9 more
openaire   +6 more sources

Unravelling the nature of non-specific effects of vaccines—A challenge for innate immunologists [PDF]

Seminars in Immunology, 2016
Epidemiological observations have shown that vaccines can influence morbidity and mortality more than can be ascribed to target-disease immunity. A growing number of immunological studies have helped identify possible biological mechanisms to explain these so-called nonspecific effects (NSE) of vaccines, including heterologous T-cell reactivity and ...
Kristoffer Jarlov Jensen, Christine Stabell Benn, Reinout van Crevel   +2 more
openaire   +3 more sources

The origin of non-specific effects of vaccines and the role of randomised clinical trials [PDF]

Human Vaccines & Immunotherapeutics
Recent articles claim that randomized clinical trials (RCTs) have not documented non-specific effects of vaccines (NSE), i.e. broader immunomodulatory effects of vaccines. We reviewed the role of RCTs in the discovery of NSEs.
Christine S. Benn, Sebastian Nielsen, Frederik Schaltz-Buchholzer, Peter Aaby   +3 more
doaj   +2 more sources

The non-specific effects of vaccines in low income countries [PDF]

Archives of Disease in Childhood, 2010
In their commentary on my article about the non-specific effects of vaccines, Paul Fine and David Elliman state that we are dealing with ‘unproven non-specific effects’ and imply that these effects may not be of widespread importance because ‘much of the evidence’ comes from Guinea-Bissau.1 First, proof is never possible in medicine.
F. Shann
openaire   +2 more sources

Non-specific effects of MMR vaccines on infectious disease related hospitalizations during the second year of life in high-income countries: a systematic review and meta-analysis

Human Vaccines & Immunotherapeutics, 2020
Children who had received MMR as the most recent vaccine had a pooled 35% (95%CI: 12–53%) lower risk for hospitalization due to any infectious disease, compared to children who had received DTaP as the most recent vaccine (three studies, 1,919,192 ...
Andrea Xaver Sinzinger, Rüdiger Von Kries, Anette Siedler, Ole Wichmann, Thomas Harder   +4 more
doaj   +2 more sources

Compartment models for vaccine effectiveness and non-specific effects for Tuberculosis

Mathematical Biosciences and Engineering, 2019
In this paper, we attempt to set a framework of conditions for model-specific predictions of newly arising TB epidemics by e.g. immigration of infected persons from high prevalence countries. In addition, we address the aspect of trained immunity in our model.
Sarah Treibert, Helmut Brunner, Matthias Ehrhardt   +2 more
openaire   +4 more sources

Non-specific effects of vaccinations in high-income settings: How to address the issue?

Human Vaccines & Immunotherapeutics, 2018
“Non-specific effects” of vaccines go beyond the specific protective effects against the targeted diseases. They, if real, could theoretically be beneficial, neutral or negative. This article intends to answer the following questions: Do the non-specific
Alberto Donzelli, Alessandro Schivalocchi, Giulia Giudicatti   +2 more
doaj   +2 more sources